Translation in Mitochondria and Other Organelles

  • Anne-Marie Duchêne

Table of contents

  1. Front Matter
    Pages i-vi
  2. Manjuli R. Sharma, Prem S. Kaushal, Mona Gupta, Nilesh K. Banavali, Rajendra K. Agrawal
    Pages 1-28
  3. Catherine Florentz, Joern Pütz, Frank Jühling, Hagen Schwenzer, Peter F. Stadler, Bernard Lorber et al.
    Pages 55-83
  4. Ivan Tarassov, Ivan Chicherin, Yann Tonin, Alexandre Smirnov, Petr Kamenski, Nina Entelis
    Pages 85-107
  5. Steffi Gruschke, Martin Ott
    Pages 109-131
  6. Dmitri A. Maslov, Rajendra K. Agrawal
    Pages 133-157
  7. Ankit Gupta, Afreen Haider, Suniti Vaishya, Saman Habib
    Pages 159-179
  8. Thalia Salinas, Claire Remacle, Laurence Maréchal-Drouard
    Pages 181-205
  9. Masahiro Sugiura
    Pages 207-224
  10. Nunzia Scotti, Michele Bellucci, Teodoro Cardi
    Pages 225-262
  11. Back Matter
    Pages 263-265

About this book


The present book gives an overview on the similarities and differences of the various translation systems. Moreover, it highlights the mechanisms and control of translation in mitochondria and other organelles such as plastids and apicoplasts in different organisms. Lastly, it offers an outlook on future developments and applications that might be made possible by a better understanding of translation in mitochondria and other organelles. 

Mitochondria and plastids originate from the endosymbiosis of bacteria. Over the course of evolution, most of the bacterial genes have been lost or transferred to the nuclear genome. Present-day mitochondria and plastids retain only a vestige of the genome of the ancestral bacteria, but the few organellar-encoded protein genes remain essential and must be translated.

Organellar translation machineries present clear specificities compared to cytosolic translation machineries, but also from one organism to the other. The organellar translation machineries appear to consist of organellar-encoded and nucleus-encoded components. They rely on crosstalk between genomes and are predominantly controlled by specific mechanisms. Organellar ribosomes show clear differences compared to the ancestral bacterial ribosomes or to the cytosolic ones. Moreover, transfer RNAs and aminoacyl-tRNA synthetases are key components of protein-synthesizing systems, and a full set of both types of macromolecules is required in each compartment where translation occurs.

Organellar translations are increasingly becoming a subject of investigation. Translation dysfunctions in human mitochondria are responsible for numerous diseases, and organellar translation systems in some parasites offer potential targets for drug development. Lastly, chloroplasts can be used as platforms for the production of recombinant proteins.


Cell organelles Mitochondria Organellar translation Protein biosynthesis Translation mechanisms

Editors and affiliations

  • Anne-Marie Duchêne
    • 1
  1. 1.Institut de Biologie Moleculaire des PlantesStrasbourg CXFrance

Bibliographic information