Dynamics in Enzyme Catalysis

  • Judith Klinman
  • Sharon Hammes- Schiffer

Part of the Topics in Current Chemistry book series (TOPCURRCHEM, volume 337)

Table of contents

About this book


Christopher M. Cheatum and Amnon Kohen
Relationship of Femtosecond–Picosecond Dynamics to Enzyme-Catalyzed H-Transfer

Cindy Schulenburg and Donald Hilvert
Protein Conformational Disorder and Enzyme Catalysis

A. Joshua Wand, Veronica R. Moorman and Kyle W. Harpole
A Surprising Role for Conformational Entropy in Protein Function

Travis P. Schrank, James O. Wrabl and Vincent J. Hilser
Conformational Heterogeneity Within the LID Domain Mediates Substrate Binding to Escherichia coli Adenylate Kinase: Function Follows Fluctuations

Buyong Ma and Ruth Nussinov
Structured Crowding and Its Effects on Enzyme Catalysis

Michael D. Daily, Haibo Yu, George N. Phillips Jr and Qiang Cui
Allosteric Activation Transitions in Enzymes and Biomolecular Motors: Insights from Atomistic and Coarse-Grained Simulations

Karunesh Arora and Charles L. Brooks III
Multiple Intermediates, Diverse Conformations, and Cooperative Conformational Changes Underlie the Catalytic Hydride Transfer Reaction of Dihydrofolate Reductase

Steven D. Schwartz
Protein Dynamics and the Enzymatic Reaction Coordinate


Allostery Cellular allosteric relay Conformational disorder Conformational entropy Enzyme reaction coordinates GTPases Judith Klinman Mechanochemical coupling Protein Dynamics Sharon Hammes-Schiffer

Editors and affiliations

  • Judith Klinman
    • 1
  • Sharon Hammes- Schiffer
    • 2
  1. 1.Department of Chemistry Department of Molecular and Cell BiologyUniversity of California The california institute for QuantitativBerkeley, CAUSA
  2. 2.Department of ChemistryUniversity of Illinois at Urbana-ChampaiUrbana, IllinoisUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2013
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-642-38961-0
  • Online ISBN 978-3-642-38962-7
  • Series Print ISSN 0340-1022
  • Series Online ISSN 1436-5049
  • Buy this book on publisher's site