Mosaicism in Human Skin

Understanding Nevi, Nevoid Skin Disorders, and Cutaneous Neoplasia

  • Rudolf Happle

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Rudolf Happle
    Pages 1-2
  3. The Mechanisms of Cutaneous Mosaicism

    1. Front Matter
      Pages 3-3
    2. Rudolf Happle
      Pages 5-12
    3. Rudolf Happle
      Pages 13-37
  4. The Patterns of Cutaneous Mosaicism

    1. Front Matter
      Pages 43-43
    2. Rudolf Happle
      Pages 45-61
  5. Mosaic Skin Disorders

    1. Front Matter
      Pages 67-67
    2. Rudolf Happle
      Pages 69-108
    3. Rudolf Happle
      Pages 109-114
    4. Rudolf Happle
      Pages 177-181
    5. Rudolf Happle
      Pages 183-219
    6. Rudolf Happle
      Pages 221-222
  6. Back Matter
    Pages 223-229

About this book


Mosaicism is a powerful biologic concept, originally developed from the study of plants and animals, and is the necessary basis for the explanation of numerous human skin disorders.


This lavishly illustrated book presents, for the first time, a comprehensive overview of the strikingly manifold patterns and peculiarities of mosaic skin disorders. It is structured in a straightforward, reader-friendly way that will help the dermatologist to understand the underlying molecular mechanisms of skin disorders in order to further improve the treatment outcome. The first two parts of the book are devoted to the mechanisms and patterns of cutaneous mosaicism, with explanation of genomic and epigenetic mosaicism and description of the six archetypal patterns, including the lines of Blaschko, as well as less well defined or as yet unclassifiable patterns. In the third part, the various mosaic skin disorders are examined in depth, including nevi, allelic and non-allelic didymosis, other binary genodermatoses, mosaic manifestations of autosomal dominant skin disorders, and nevoid skin disorders. The book concludes with a note on neoplastic skin lesions, examining models of tumorigenesis.


Genetics Lethal mutations Lines of Blaschko Nevi Skin disorders

Authors and affiliations

  • Rudolf Happle
    • 1
  1. 1.Department of DermatologyFreiburg University Medical CenterFreiburgGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2014
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-642-38764-7
  • Online ISBN 978-3-642-38765-4
  • Buy this book on publisher's site