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Protein-Nanoparticle Interactions

The Bio-Nano Interface

  • Masoud Rahman
  • Sophie Laurent
  • Nancy Tawil
  • L'Hocine Yahia
  • Morteza Mahmoudi

Part of the Springer Series in Biophysics book series (BIOPHYSICS, volume 15)

Table of contents

  1. Front Matter
    Pages i-x
  2. Masoud Rahman, Sophie Laurent, Nancy Tawil, L’Hocine Yahia, Morteza Mahmoudi
    Pages 1-20
  3. Masoud Rahman, Sophie Laurent, Nancy Tawil, L’Hocine Yahia, Morteza Mahmoudi
    Pages 21-44
  4. Masoud Rahman, Sophie Laurent, Nancy Tawil, L’Hocine Yahia, Morteza Mahmoudi
    Pages 45-63
  5. Masoud Rahman, Sophie Laurent, Nancy Tawil, L’Hocine Yahia, Morteza Mahmoudi
    Pages 65-82
  6. Back Matter
    Pages 83-84

About this book

Introduction

In recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediately covered by biomolecules (e.g. proteins, ions, and enzymes) upon their entrance into a biological medium. This interaction with the biological medium modulates the surface of the nanoparticles, conferring a “biological identity” to their surfaces (referred to as a “corona”), which determines the subsequent cellular/tissue responses. The new interface between the nanoparticles and the biological medium/proteins, called “bio-nano interface,” has been very rarely studied in detail to date, though the interest in this topic is rapidly growing.

In this book, the importance of the physiochemical characteristics of nanoparticles for the properties of the protein corona is discussed in detail, followed by comprehensive descriptions of the methods for assessing the protein-nanoparticle interactions. The advantages and limitations of available corona evaluation methods (e.g. spectroscopy methods, mass spectrometry, nuclear magnetic resonance, electron microscopy, X-ray crystallography, and differential centrifugal sedimentation) are examined in detail, followed by a discussion of the possibilities for enhancing the current methods and a call for new techniques. Moreover, the advantages and disadvantages of protein-nanoparticle interaction phenomena are explored and discussed, with a focus on the biological impacts.

Keywords

Molecular Dynamics Nano-Bio Interface Nanoscience and Nanotechnology Protein Conformation Protein Corona

Authors and affiliations

  • Masoud Rahman
    • 1
  • Sophie Laurent
    • 2
  • Nancy Tawil
    • 3
  • L'Hocine Yahia
    • 4
  • Morteza Mahmoudi
    • 5
  1. 1.Department of Chemical Engineering and, Materials ScienceUniversity of California in DavisDavisUSA
  2. 2.NanoBio Interactions Laboratory, Department of NanotechnologyTehran University of Medical SciencesTehranIran
  3. 3.Laboratoire d'Innovation et, d'Analyse de BioperformanceÉcole Polytechnique de MontréalMontrealCanada
  4. 4.Laboratoire d'Innovation et, d'Analyse de BioperformanceÉcole Polytechnique de MontréalMontrealCanada
  5. 5.Pasteur Institute of Iran, National Cell BankNanoBio Interactions LaboratoryTehranIran

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-37555-2
  • Copyright Information Springer-Verlag Berlin Heidelberg 2013
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Physics and Astronomy
  • Print ISBN 978-3-642-37554-5
  • Online ISBN 978-3-642-37555-2
  • Series Print ISSN 0932-2353
  • Series Online ISSN 1868-2561
  • Buy this book on publisher's site