Environmental Epigenomics in Health and Disease

Epigenetics and Complex Diseases

  • Randy L. Jirtle
  • Frederick L. Tyson

Part of the Epigenetics and Human Health book series (EHH)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Epigenetic Programming of the Brain

  3. Epigenetics and Neurological Disorders

    1. Front Matter
      Pages 55-55
    2. Janine M. LaSalle, Roxanne O. Vallero, Michelle M. Mitchell
      Pages 97-114
    3. Hsien-Sung Huang, Benjamin D. Philpot, Yong-hui Jiang
      Pages 167-193
  4. Epigenetics, Nutrition, Diabetes, and Obesity

    1. Front Matter
      Pages 195-195
    2. Janos Zempleni, Dandan Liu, Jing Xue
      Pages 197-217
    3. Caroline L. Relton, George Davey-Smith, Susan E. Ozanne
      Pages 235-253
  5. Epigenetics and Cancer

    1. Front Matter
      Pages 255-255
    2. F. Javier Carmona, Manel Esteller
      Pages 269-293
  6. Epigenetics and the Law

    1. Front Matter
      Pages 295-295
    2. Mark A. Rothstein
      Pages 297-308
  7. Back Matter
    Pages 309-339

About this book


The capacity of the epigenome to interpret both internal and external stimuli and alter expression programs is a critical component in normal development, aging, and disease pathogenesis. In the past decade, we have witnessed an explosion of unprecedented research on and support for epigenetics, epigenomics, and their interface with human health and disease. In this volume, Environmental Epigenomics in Health and Disease - Epigenetics and Complex Diseases, a number of leading investigators in the field of epigenetics discuss patterns of epigenomic modifications in normal cells, and how environmentally-induced changes in them are associated with disease pathogenesis. The authors comprehensively review the epigenetic adaptations that occur in human embryonic stem cells, as well as in differentiating cells and organs such as the brain when exposed to environmental factors, and discuss the legal and ethical implications of such alterations. The overall purpose of this volume and its companion, Environmental Epigenomics in Health and Disease - Epigenetics and Disease Origins, is to give readers an overview of how environmental exposures during early development can influence disease formation by disrupting epigenetic programming.


DNA methylation chromatin switching epigenetic programming human cancer epigenetics imprinting social environment

Editors and affiliations

  • Randy L. Jirtle
    • 1
  • Frederick L. Tyson
    • 2
  1. 1., Department of OncologyUniversity of Wisconsin-MadisonMadisonUSA
  2. 2.National Institute of Environmental Hea, NIEHSNational Institutes of HealthResearch Triangle ParkUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2013
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-36826-4
  • Online ISBN 978-3-642-36827-1
  • Series Print ISSN 2191-2262
  • Series Online ISSN 2191-2270
  • Buy this book on publisher's site