Evolution of Extracellular Matrix

  • Fred W. Keeley
  • Robert P. Mecham

Part of the Biology of Extracellular Matrix book series (BEM)

Table of contents

  1. Front Matter
    Pages i-x
  2. Josephine C. Adams
    Pages 1-25
  3. Jean-Yves Exposito, Claire Lethias
    Pages 39-72
  4. Fred W. Keeley
    Pages 73-119
  5. Sacha Jensen, David Yadin, Ian Robertson, Penny Handford
    Pages 121-162
  6. David D. Roberts, William A. Frazier
    Pages 221-242
  7. Mark S. Johnson, Jarmo Käpylä, Konstantin Denessiouk, Tomi Airenne, Bhanupratap Singh Chouhan, Jyrki Heino
    Pages 243-283
  8. Mark S. Johnson, Jarmo Käpylä, Konstantin Denessiouk, Tomi Airenne, Bhanupratap Singh Chouhan, Jyrki Heino
    Pages E1-E5
  9. Back Matter
    Pages 285-290

About this book


The evolution of single cells into multicellular organisms was mediated, in large part, by the extracellular matrix. The proteins and glycoconjugates that make up the extracellular matrix provide structural support to cellular complexes, facilitate cell adhesion and migration, and impart mechanical properties that are important for tissue function. Each class of ECM macromolecule has evolved to incorporate distinctive properties that are defined by conserved modules that are mixed together to achieve appropriate function.  This volume provides a comprehensive analysis of how the major ECM components evolved over time in order to fill their specific roles found in modern organisms. The major focus is on the structural matrix proteins, matricellular proteins, and more complex ECM structures such as basement membranes. Adhesive proteins and their receptors are also discussed.

The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.


Angiogenesis Cell Adhesion Collagen Elastin Fibrin Fibrosis

Editors and affiliations

  • Fred W. Keeley
    • 1
  • Robert P. Mecham
    • 2
  1. 1.Hospital for Sick ChildrenTorontoCanada
  2. 2.Dept. Cell Biology & PhysiologyWashington University School of MedicineSt. LouisUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2013
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-36001-5
  • Online ISBN 978-3-642-36002-2
  • Series Print ISSN 0887-3224
  • Series Online ISSN 2191-1959
  • Buy this book on publisher's site