Extracellular Matrix in Development

  • Douglas W. DeSimone
  • Robert P. Mecham

Part of the Biology of Extracellular Matrix book series (BEM)

Table of contents

  1. Front Matter
    Pages i-x
  2. Informational Signals in Extracellular Matrix and Matrix Influences on Cell Movement in the Developing Embryo

    1. Front Matter
      Pages 1-1
    2. Andras Czirok, Brenda J. Rongish, Charles D. Little
      Pages 19-36
    3. Bette J. Dzamba, Douglas W. DeSimone
      Pages 37-72
  3. Extracellular Matrix-Direct Morphogenesis, Growth Factor Signaling, and Maintenance of the Stem Cell Niche

  4. Model Organisms and the Lexicon of Developmental Signals Associated with the Extracellular Matrix

    1. Front Matter
      Pages 161-161
    2. Xiaoming Zhang, Michael P. Sarras Jr
      Pages 163-186
    3. Nathan A. Mundell, Jason R. Jessen
      Pages 187-218
    4. Peter J. Roughley, Pierre Moffatt
      Pages 219-247
  5. Back Matter
    Pages 249-253

About this book


Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.

The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.


Amphibian gastrulation Epithelia Growth factor signaling Organ morphogenesis Skeleton Stem cells

Editors and affiliations

  • Douglas W. DeSimone
    • 1
  • Robert P. Mecham
    • 2
  1. 1.School of Medicine, Department of Cell BiologyUniversity of VirginiaCharlottesvilleUSA
  2. 2.School of Medicine, Dept. Cell Biology & PhysiologyWashington UniversitySt. LouisUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2013
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-35934-7
  • Online ISBN 978-3-642-35935-4
  • Series Print ISSN 0887-3224
  • Series Online ISSN 2191-1959
  • Buy this book on publisher's site