CRISPR-Cas Systems

RNA-mediated Adaptive Immunity in Bacteria and Archaea

  • Rodolphe Barrangou
  • John van der Oost

Table of contents

  1. Front Matter
    Pages i-x
  2. Francisco J. M. Mojica, Roger A. Garrett
    Pages 1-31
  3. Christine Pourcel, Christine Drevet
    Pages 33-59
  4. Zihni Arslan, Edze R. Westra, Rolf Wagner, Ümit Pul
    Pages 93-113
  5. Emmanuelle Charpentier, John van der Oost, Malcolm F. White
    Pages 115-144
  6. Raymond H. J. Staals, Stan J. J. Brouns
    Pages 145-169
  7. Marie-Ève Dupuis, Sylvain Moineau
    Pages 171-200
  8. Asma Hatoum-Aslan, Kelli L. Palmer, Michael S. Gilmore, Luciano A. Marraffini
    Pages 201-219
  9. Nicole L. Held, Lauren M. Childs, Michelle Davison, Joshua S. Weitz, Rachel J. Whitaker, Devaki Bhaya
    Pages 221-250
  10. Gil Amitai, Rotem Sorek
    Pages 251-266
  11. Philippe Horvath, Giedrius Gasiunas, Virginijus Siksnys, Rodolphe Barrangou
    Pages 267-286
  12. Jillian F. Banfield
    Pages 287-291
  13. Back Matter
    Pages 293-299

About this book


CRISPR-Cas is a recently discovered defense system which protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR-Cas immune systems has been identified in at least half of the available prokaryotic genomes. On-going biochemical and functional analyses have resulted in substantial insight into the functions and possible applications of these fascinating systems, although many secrets remain to be uncovered.

In this book, experts summarize the state of the art of this exciting field.


Acquired immunity Archaea Bacterial Genome CRISPR Virus

Editors and affiliations

  • Rodolphe Barrangou
    • 1
  • John van der Oost
    • 2
  1. 1.DuPont Nutrition and HealthMadisonUSA
  2. 2., Laboratory of MicrobiologyUniversity of WageningenWageningenNetherlands

Bibliographic information