Clinical Cases in Primary Immunodeficiency Diseases

A Problem-Solving Approach

  • Asghar Aghamohammadi
  • Nima Rezaei

Table of contents

  1. Front Matter
    Pages i-xix
  2. Asghar Aghamohammadi, Hassan Abolhassani, Fabiola Caracseghi, Pere Soler-Palacin
    Pages 1-75
  3. Francisco A. Bonilla, Isil B. Barlan, Elif Aydiner, Waleed Al-Herz, Martha M. Eibl, Teresa Espanol et al.
    Pages 77-112
  4. Asghar Aghamohammadi, Hassan Abolhassani, Martha M. Eibl, Teresa Espanol, Hirokazu Kanegane, Toshio Miyawaki et al.
    Pages 113-192
  5. Nima Rezaei, Asghar Aghamohammadi, Michael H. Albert, Bernd H. Belohradsky, Teresa Espanol, Melinda Erdős et al.
    Pages 193-231
  6. Shinsaku Imashuku, Melinda Erdős, Waleed Al-Herz, Mohammad Hassan Bemanian, Hirokazu Kanegane, László Maródi et al.
    Pages 233-277
  7. Melinda Erdős, László Maródi, Seyed Alireza Mahdaviani, Sergio D. Rosenzweig, Joachim Roesler, Nima Rezaei
    Pages 279-307
  8. Per Wekell, Anders Fasth, Stefan Berg
    Pages 309-324
  9. Kathleen Sullivan, Martha M. Eibl, Melinda Erdős, László Maródi, Hermann M. Wolf, Maryam Mahmoudi et al.
    Pages 325-341
  10. Teresa Espanol, Cristina Fillat, Isil B. Barlan, Elif Aydiner, Fabiola Caracseghi, Tim Niehues et al.
    Pages 343-368
  11. Back Matter
    Pages 369-377

About this book


Primary immunodeficiency diseases (PIDs) are a heterogeneous group of inherited disorders characterized by different defects in the development and function of the immune system. These defects render patients susceptible to a variety of infectious diseases. Knowledge of normal immunity and specific warning signs and symptoms can help physicians to identify those children with underlying PIDs.

This book aims to increase the clinical awareness and knowledge of practicing clinicians regarding the diagnosis and management of PIDs. In order to achieve this goal, about 90 cases drawn from real life are presented, along with approximately 300 related questions. The selected case reports are the result of the invaluable cooperation of more than 40 scientists in the field of immunodeficiency. They focus both on the presenting features of patients with PIDs and on the required further investigation and management. Although the case scenarios relate to real histories, some modifications have been made for educational purposes. Each of the numbered cases is followed by the questions, their answers, and additional discussion. Each question focuses on a particular aspect of the PID under consideration, and the topics covered include clinical diagnosis, laboratory findings, molecular mechanisms, and therapy.

This practical, case-oriented book will be an invaluable source of guidance on the diagnosis and treatment of patients with PIDs and will be relevant for those working in a variety of specialties and subspecialties.


Immunology Lymphocytes PID Recurrent Infections Single-gene defect

Editors and affiliations

  • Asghar Aghamohammadi
    • 1
  • Nima Rezaei
    • 2
  1. 1.Research Center for Immunodeficiencies, Children's Medical Center HospitalTehran University of Medical SciencesTehranIran
  2. 2.Research Center for Immunodeficiencies, Children's Medical Center HospitalTehran University of Medical SciencesTehranIran

Bibliographic information