Neutron Capture Therapy

Principles and Applications

  • Wolfgang Sauerwein
  • Andrea Wittig
  • Raymond Moss
  • Yoshinobu Nakagawa

Table of contents

  1. Front Matter
    Pages i-ix
  2. Wolfgang A. G. Sauerwein
    Pages 1-16
  3. Neutron sources

    1. Front Matter
      Pages 17-17
    2. Andres J. Kreiner
      Pages 41-54
    3. Ka-Ngo Leung
      Pages 55-67
  4. Boron

    1. Front Matter
      Pages 75-75
    2. Luigi Panza, Davide Prosperi
      Pages 77-98
    3. Hiroyuki Nakamura, Mitsunori Kirihata
      Pages 99-116
    4. Wolfgang A. G. Sauerwein, Pierre M. Bet, Andrea Wittig
      Pages 117-160
  5. Analysis and Imaging

    1. Front Matter
      Pages 161-161
    2. Andrea Wittig, Wolfgang A. G. Sauerwein
      Pages 163-188
    3. Pier Luigi Mauri, Fabrizio Basilico
      Pages 189-200
    4. Tadashi Nariai, Kiichi Ishiwata
      Pages 201-212
  6. Physics

    1. Front Matter
      Pages 225-225
    2. Per Munck af Rosenschöld
      Pages 259-275
    3. Jürgen Rassow, Wolfgang A. G. Sauerwein
      Pages 277-285
    4. W. S. Kiger III, Hiroaki Kumada
      Pages 287-326
  7. Biology

    1. Front Matter
      Pages 327-327
    2. John W. Hopewell, Gerard M. Morris, Amanda E. Schwint, Jeffrey A. Coderre
      Pages 329-358
    3. Yoshinobu Nakagawa, Teruyoshi Kageji
      Pages 359-365
  8. Clinical Applications

    1. Front Matter
      Pages 367-367
    2. Andrea Wittig, Wolfgang A. G. Sauerwein
      Pages 369-376
    3. Tetsuya Yamamoto, Akira Matsumura
      Pages 377-388
    4. Shinji Kawabata, Shin-Ichi Miyatake
      Pages 399-406
    5. Kei Nakai, Akira Matsumura
      Pages 407-415
    6. Teruhito Aihara, Norimasa Morita
      Pages 417-424
    7. Mario A. Pisarev, Maria A. Dagrosa, Guillermo J. Juvenal
      Pages 425-431
    8. Junichi Hiratsuka, Hiroshi Fukuda
      Pages 433-448
    9. A. Zonta, L. Roveda, S. Altieri
      Pages 461-503
    10. Yoshinobu Nakagawa, Teruyoshi Kageji
      Pages 505-511
    11. Wataro Tsuruta, Tetsuya Yamamoto, Akira Matsumura
      Pages 513-520
    12. Jacquelyn C. Yanch
      Pages 521-530
  9. Organizational Aspects and Management

    1. Front Matter
      Pages 531-531
    2. Wolfgang A. G. Sauerwein, Ray Moss
      Pages 533-542
  10. Back Matter
    Pages 543-553

About this book


Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter. This in principle allows for tumor cell-selective high-LET particle radiotherapy. NCT is exciting scientifically but challenging clinically, and a key factor in success is close collaboration among very different disciplines.

This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.


Boron Neutron Capture Therapy (NCT) Particle Therapy Radiation Oncology Targeted Therapies

Editors and affiliations

  • Wolfgang Sauerwein
    • 1
  • Andrea Wittig
    • 2
  • Raymond Moss
    • 3
  • Yoshinobu Nakagawa
    • 4
  1. 1.Zentrum für Konservative Onkologie, Klinik für StrahlentherapieUniv.Klinikum EssenEssenGermany
  2. 2.Philipps-University Marburg, Department of Radiation OncologyUniversity Hospital Marburg,MarburgGermany
  3. 3.Joint Research Centre, Institute for EngergyEuropean CommissionLE PettenNetherlands
  4. 4., Department of NeurosurgeryKagawa National Children's HospitalZentsujiJapan

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2012
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-642-31333-2
  • Online ISBN 978-3-642-31334-9
  • Buy this book on publisher's site