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Henipavirus

Ecology, Molecular Virology, and Pathogenesis

  • Benhur Lee
  • Paul A. Rota

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 359)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Hume Field, Gary Crameri, Nina Yu-Hsin Kung, Lin-Fa Wang
    Pages 11-23
  3. Stephen P. Luby, Emily S. Gurley
    Pages 25-40
  4. Paul A. Rota, Michael K. Lo
    Pages 41-58
  5. Olivier Pernet, Yao E Wang, Benhur Lee
    Pages 59-78
  6. Hector C. Aguilar, Ronald M. Iorio
    Pages 79-94
  7. D. J. Middleton, H. M. Weingartl
    Pages 105-121
  8. Thomas W. Geisbert, Heinz Feldmann, Christopher C. Broder
    Pages 153-177
  9. Christopher C. Broder, Thomas W. Geisbert, Kai Xu, Dimitar B. Nikolov, Lin-Fa Wang, Deborah Middleton et al.
    Pages 197-223
  10. Back Matter
    Pages 225-226

About this book

Introduction

Henipaviruses form a new genus of emerging paramyxoviruses that are the deadliest human pathogens within the Paramyxoviridae family. This volume deals with the many facets of henipavirus biology, and covers our current understanding regarding the ecology, molecular virology, and pathogenesis of henipavirus infections. It is an international effort written by a multidisciplinary panel of experts at the front lines of research into this lethal emerging group of paramyxoviruses. The first section introduces the epidemiology and ecology of Nipah and Hendra viruses in their respective endemic areas, including a first-hand account of the discovery of Nipah virus during its initial outbreak in Malaysia; the next section documents the molecular virology of henipaviruses, and the substantial advances made towards understanding the unique features of henipavirus entry and tropism; and this is followed by accounts of the clinical and pathologic features of henipavirus infections in their human and naturally infected animal hosts. The next sections on pathogenesis provide a comprehensive reference on how henipaviruses counteract the innate immune system, and the relevant pathogenic features in animal challenge models developed to test potential therapeutic strategies. The final sections describe our current and future capabilities for diagnosis and control, including an account of potentially effective immunization strategies that are currently being tested. 

 

This book will not only serve as a useful reference for the henipavirus field; it will be useful to basic and animal virologists, ecologists, epidemiologists, physicians, and others interested in emerging infectious viral diseases, as it showcases the multidisciplinary efforts required to understand the genesis, spread and hopefully, control, of a group of lethal emerging zoonotic pathogens.  

Keywords

Hendra virus Nipah virus encephalitic illness respiratory illness zoonotic diseases

Editors and affiliations

  • Benhur Lee
    • 1
  • Paul A. Rota
    • 2
  1. 1., Dept. of Microbiol., Immunol., Mol. Gen.David Geffen School of MedicineLos AngelesUSA
  2. 2.AtlantaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-29819-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 2012
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-29818-9
  • Online ISBN 978-3-642-29819-6
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site