Purinergic Signalling and the Nervous System

  • Geoffrey Burnstock
  • Alexei Verkhratsky

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Geoffrey Burnstock, Alexei Verkhratsky
    Pages 1-6
  3. Geoffrey Burnstock, Alexei Verkhratsky
    Pages 7-66
  4. Geoffrey Burnstock, Alexei Verkhratsky
    Pages 67-77
  5. Geoffrey Burnstock, Alexei Verkhratsky
    Pages 79-118
  6. Geoffrey Burnstock, Alexei Verkhratsky
    Pages 119-244
  7. Geoffrey Burnstock, Alexei Verkhratsky
    Pages 245-305
  8. Geoffrey Burnstock, Alexei Verkhratsky
    Pages 307-432
  9. Geoffrey Burnstock, Alexei Verkhratsky
    Pages 433-581
  10. Geoffrey Burnstock, Alexei Verkhratsky
    Pages 583-625
  11. Geoffrey Burnstock, Alexei Verkhratsky
    Pages 627-679
  12. Geoffrey Burnstock, Alexei Verkhratsky
    Pages 681-707
  13. Back Matter
    Pages 709-715

About this book

Introduction

In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act as an extracellular signalling molecule. However, after the receptors for ATP and adenosine were cloned and characterized in the early 1990s and ATP was established as a synaptic transmitter in the brain and sympathetic ganglia, the tide turned. More recently it has become clear that ATP is involved in long-term (trophic) signalling in cell proliferation, differentiation and death, in development and regeneration, as well as in short-term signalling in neurotransmission and secretion. Also, important papers have been published showing the molecular structure of P2X receptors in primitive animals like Amoeba and Schistosoma, as well as green algae. This has led to the recognition of the widespread nature of the purinergic signalling system in most cell types and to a rapid expansion of the field, including studies of the pathophysiology as well as physiology and exploration of the therapeutic potential of purinergic agents.

In two books, Geoffrey Burnstock and Alexej Verkhratsky have aimed at drawing together the massive and diverse body of literature on purinergic signalling. The topic of this first book is purinergic signalling in the peripheral and central nervous systems and in the individual senses. In a second book the authors focus on purinergic signalling in non-excitable cells, including those of the airways, kidney, pancreas, endocrine glands and blood vessels. Diseases related to these systems are also considered.

Keywords

Adenosine triphosphate (ATP) Cardio-vascular system Purinergic signalling Signalling endocrine system gastrointestinal system muscle system reproductory system respiratory system skeletal system

Authors and affiliations

  • Geoffrey Burnstock
    • 1
  • Alexei Verkhratsky
    • 2
  1. 1.Medical School, Autonomic Neuroscience InstituteRoyal Free and University CollegeLondonUnited Kingdom
  2. 2.School of Biological SciencesUniversity of ManchesterManchesterUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-28863-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 2012
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-28862-3
  • Online ISBN 978-3-642-28863-0
  • About this book