Protein Quality Control in Neurodegenerative Diseases

  • Richard I. Morimoto
  • Yves Christen

Part of the Research and Perspectives in Alzheimer's Disease book series (ALZHEIMER)

Table of contents

About this book


The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding., translocation, and clearance of proteins. The cell is challenged constantyl by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.


autophagy cellular defense cytoplasmic degradation neuronal control protein homeostasis

Editors and affiliations

  • Richard I. Morimoto
    • 1
  • Yves Christen
    • 2
  1. 1.Morimoto LabNorthwestern UniversityEvanstonUSA
  2. 2.Fondation IPSENBoulogne-Billancourt CedexFrance

Bibliographic information