Hepatitis C Virus: From Molecular Virology to Antiviral Therapy

  • Ralf Bartenschlager

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 369)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Peter Simmonds
    Pages 1-15
  3. Eike Steinmann, Thomas Pietschmann
    Pages 17-48
  4. Eva Billerbeck, Ype de Jong, Marcus Dorner, Cynthia de la Fuente, Alexander Ploss
    Pages 49-86
  5. Mirjam B. Zeisel, Daniel J. Felmlee, Thomas F. Baumert
    Pages 87-112
  6. Darius Moradpour, François Penin
    Pages 113-142
  7. Michael Niepmann
    Pages 143-166
  8. Volker Lohmann
    Pages 167-198
  9. Brett D. Lindenbach
    Pages 199-218
  10. John W. Schoggins, Charles M. Rice
    Pages 219-242
  11. Christoph Neumann-Haefelin, Robert Thimme
    Pages 243-262
  12. Daisuke Yamane, David R. McGivern, Takahiro Masaki, Stanley M. Lemon
    Pages 263-288
  13. Leen Delang, Johan Neyts, Inge Vliegen, Sergio Abrignani, Petra Neddermann, Raffaele De Francesco
    Pages 289-320
  14. Jean-Michel Pawlotsky
    Pages 321-342
  15. Back Matter
    Pages 343-346

About this book


Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.


Chronic liver disease Disease pathogenesis HCV entry Immune response RNA replication RNA translation

Editors and affiliations

  • Ralf Bartenschlager
    • 1
  1. 1.Hygiene Institut, Abt. Molekulare VirologieUniversitätsklinikum HeidelbergHeidelbergGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-27340-7
  • Copyright Information Springer-Verlag Berlin Heidelberg 2013
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-27339-1
  • Online ISBN 978-3-642-27340-7
  • Series Print ISSN 0070-217X
  • About this book