Environmental Epigenomics in Health and Disease

Epigenetics and Disease Origins

  • Randy L Jirtle
  • Frederick L. Tyson

Part of the Epigenetics and Human Health book series (EHH)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Fetal Origins of Adult Disease Susceptibility

    1. Front Matter
      Pages 1-1
    2. Peter D. Gluckman, Felicia M. Low, Mark A. Hanson
      Pages 31-50
    3. Susan K. Murphy, Cathrine Hoyo
      Pages 51-73
  3. Epigenetics and Environmental Exposures

    1. Front Matter
      Pages 75-75
    2. Christopher Faulk, Dana C. Dolinoy
      Pages 77-97
    3. Olga Kovalchuk
      Pages 99-126
    4. Kenneth S. Ramos, Ivo Teneng, Diego E. Montoya-Durango, Pasano Bojang, Mark T. Haeberle, Irma N. Ramos et al.
      Pages 127-160
  4. Epigenetics, Gene Regulation, and Stem Cells

    1. Front Matter
      Pages 161-161
    2. Aleksandra B. Adomas, Paul A. Wade
      Pages 189-205
    3. R. David Hawkins, Bing Ren
      Pages 207-223
  5. Epigenetic Transgenerational Inheritance

    1. Front Matter
      Pages 225-225
    2. Luan Wang, Xiangyi Lu, Douglas M. Ruden
      Pages 227-244
    3. Marcus E. Pembrey, Lars O. Bygren, Jean Golding
      Pages 257-271
  6. Back Matter
    Pages 273-302

About this book


Exposure to environmental toxicants is associated with changes in DNA methylation and gene expression profiles that together can contribute to increased disease susceptibility. The chapters in this volume, Environmental Epigenomics in Health and Disease - Epigenetics and Disease Origins, address a wide range of environmental exposures, such as airborne particulates, cocaine, radiation, tobacco smoke, and xenoestrogens. Particular emphasis is placed on the consequences of environmental exposures during development on epigenetic reprogramming that influences adult disease pathogenesis. Health outcomes associated with these exposures include autoimmune disorders, neurodevelopmental disorders, and cancer. Importantly, dietary supplements and drugs can modify the epigenetic effects induced by these agents, thereby reducing their toxicological impact. The overall purpose of this volume and its companion, Environmental Epigenomics in Health and Disease - Epigenetics and Complex Diseases, is to give readers an overview of how environmental exposures during early development can influence disease formation by disrupting epigenetic processes and developmental programming.


Agouti mouse CTCF dysfunction chromatin switching endocrine disruptors environmental aromatic hydrocarbons environmental exposures genomic imprinting imprinted brain imprintome memory formation metastable epialleles

Editors and affiliations

  • Randy L Jirtle
    • 1
  • Frederick L. Tyson
    • 2
  1. 1.School of Medicine and Public Health, McArdle Laboratory for Cancer ResearchUniversity of Wisconsin-MadisonMadisonUSA
  2. 2.National Institute of Environmental Hea, NIEHSNational Institutes of HealthResearch Triangle ParkUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2013
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-23379-1
  • Online ISBN 978-3-642-23380-7
  • Series Print ISSN 2191-2262
  • Series Online ISSN 2191-2270
  • Buy this book on publisher's site