Muscarinic Receptors

  • Allison D. Fryer
  • Arthur Christopoulos
  • Neil M. Nathanson
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 208)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Muscarinic Receptor Pharmacology and Signaling

    1. Front Matter
      Pages 1-1
  3. Muscarinic receptor pharmacology and signaling

    1. Richard M. Eglen
      Pages 3-28
    2. Katie Leach, John Simms, Patrick M. Sexton, Arthur Christopoulos
      Pages 29-48
    3. Martin C. Michel, Christine A. Teitsma
      Pages 49-59
    4. Cindy Reiner, Neil M. Nathanson
      Pages 61-78
    5. Adrian J. Butcher, Kok Choi Kong, Rudi Prihandoko, Andrew B. Tobin
      Pages 79-94
  4. Muscarinic Receptors in the CNS

    1. Front Matter
      Pages 119-119
    2. Michael Bubser, Nellie Byun, Michael R. Wood, Carrie K. Jones
      Pages 121-166
    3. Amanda R. Bolbecker, Anantha Shekhar
      Pages 167-190
    4. Joshua A. Goldberg, Jun B. Ding, D. James Surmeier
      Pages 223-241
  5. Muscarinic Receptors in Autonomic Effector Organs

    1. Front Matter
      Pages 261-261
    2. Kalmia S. Buels, Allison D. Fryer
      Pages 317-341
    3. Frederick J. Ehlert, Kirk J. Pak, Michael T. Griffin
      Pages 343-374
    4. Donna J. Sellers, Russ Chess-Williams
      Pages 375-400

About this book

Introduction

Muscarinic acetylcholine receptors have played a key role in the advancement of knowledge of pharmacology and neurotransmission since the inception of studies in these fields, and the effects of naturally occurring drugs acting on muscarinic receptors were known and exploited for both therapeutic and non-therapeutic purposes for hundreds of years before the existence of the receptors themselves was recognized. This volume presents a broad yet detailed review of current knowledge of muscarinic receptors that will be valuable both to long-time muscarinic investigators and to those new to the field. It describes the detailed insights that have been obtained on the structure, function, and cell biology of muscarinic receptors. This volume also describes physiological analyses of muscarinic receptors and their roles in regulating the function of the brain and of a variety of peripheral tissues. This volume shows how the study of muscarinic receptors continues to provide new and surprising insights not just to the cholinergic system but to the broad areas of neurobiology, cell biology, pharmacology, and therapeutics.

Keywords

G-protein coupled receptor allosteric cholinergic neurotransmission translational medicine

Editors and affiliations

  • Allison D. Fryer
    • 1
  • Arthur Christopoulos
    • 2
  • Neil M. Nathanson
    • 3
  1. 1.UHN67, Department of Pulmonary and Critical CaOregon Health & Science UniversityPortlandUSA
  2. 2., Department of PharmacologyMonash Institute of Pharmaceutical ScienParkvilleAustralia
  3. 3., Department of PharmacologyUniversity of WashingtonSeattleUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-23274-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 2012
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-23273-2
  • Online ISBN 978-3-642-23274-9
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • About this book