Adenosine Deaminases Acting on RNA (ADARs) and A-to-I Editing

  • Charles E. Samuel

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 353)

Table of contents

  1. Front Matter
    Pages i-x
  2. Rena A. Goodman, Mark R. Macbeth, Peter A. Beal
    Pages 1-33
  3. Pierre Barraud, Frédéric H.-T. Allain
    Pages 35-60
  4. Bjorn-Erik Wulff, Kazuko Nishikura
    Pages 91-109
  5. Ling-Ling Chen, Gordon G. Carmichael
    Pages 111-121
  6. Charles E. Samuel
    Pages 163-195
  7. Carl R. Walkley, Brian Liddicoat, Jochen C. Hartner
    Pages 197-220
  8. Simona Paro, Xianghua Li, Mary A. O’Connell, Liam P. Keegan
    Pages 221-236
  9. Back Matter
    Pages 237-238

About this book

Introduction

The objective of this CTMI volume is to provide readers with a foundation for understanding what ADARs are and how they act to affect gene expression and function. Because A-to-I editing may affect base-pairing and RNA structure, processes including translation, splicing, RNA replication, and miR and siRNA silencing may be affected.  It also is becoming increasingly apparent that ADARs may possess roles not only as enzymes that deaminate adenosine to produce inosine in RNA substrates with double-stranded character, but also as proteins independent of their catalytic property. Future studies of ADARs no doubt will provide us with additional surprises and new insights into the modulation of biological processes by the ADAR family of proteins.

Keywords

ADAR proteins innate immunity micro RNA function neurotransmitter receptor

Editors and affiliations

  • Charles E. Samuel
    • 1
  1. 1., Dept. of Molecular, Cellular and DevelopUniversity of California, Santa BarbaraSanta BarbaraUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-22801-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 2012
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-22800-1
  • Online ISBN 978-3-642-22801-8
  • Series Print ISSN 0070-217X
  • About this book