Theory of Phase Transitions in Polypeptides and Proteins

  • Alexander V. Yakubovich

Part of the Springer Theses book series (Springer Theses)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Alexander V. Yakubovich
    Pages 1-6
  3. Alexander V. Yakubovich
    Pages 7-25
  4. Alexander V. Yakubovich
    Pages 27-54
  5. Alexander V. Yakubovich
    Pages 55-67
  6. Alexander V. Yakubovich
    Pages 69-99
  7. Alexander V. Yakubovich
    Pages 101-118
  8. Alexander V. Yakubovich
    Pages 119-121

About this book

Introduction

There are nearly 100 000 different protein sequences encoded in the human genome, each with its own specific fold. Understanding how a newly formed polypeptide sequence finds its way to the correct fold is one of the greatest challenges in the modern structural biology. The aim of this thesis is to provide novel insights into protein folding by considering the problem from the point of view of statistical mechanics.
The thesis starts by investigating the fundamental degrees of freedom in polypeptides that are responsible for the conformational transitions. This knowledge is then applied in the statistical mechanics description of helix↔coil transitions in polypeptides. Finally, the theoretical formalism is generalized to the case of proteins in an aqueous environment. The major novelty of this work lies in combining (a) a formalism based on fundamental physical properties of the system and (b) the resulting possibility of describing the folding↔unfolding transitions quantitatively. The clear physical nature of the formalism opens the way to further applications in a large variety of systems and processes.

Keywords

Hydrophobic/Hydrophilic Interactions Phase Transitions in Finite Systems Polypeptides/Macromolecular Degrees of Freedom Prize winning thesis Protein Folding Statistical Mechanics folding unfolding transitions helix coil transitions in polypeptides protein folding/unfolding transition statistical physics of protein folding

Authors and affiliations

  • Alexander V. Yakubovich
    • 1
  1. 1., Frankfurt Institute for Advanced StudiesGoethe UniversityFrankfurt am MainGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-22592-5
  • Copyright Information Springer-Verlag Berlin Heidelberg 2011
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Physics and Astronomy
  • Print ISBN 978-3-642-22591-8
  • Online ISBN 978-3-642-22592-5
  • About this book