Regulatory RNAs

Basics, Methods and Applications

  • Bibekanand Mallick
  • Zhumur Ghosh

Table of contents

  1. Front Matter
    Pages i-ix
  2. Basics

    1. Front Matter
      Pages 1-1
    2. Zhumur Ghosh, Bibekanand Mallick
      Pages 3-22
    3. Jana Nejepinska, Matyas Flemr, Petr Svoboda
      Pages 111-149
    4. Christian Barbato, Francesca Ruberti
      Pages 175-195
    5. Sally K Abd Ellatif, Tony Gutschner, Sven Diederichs
      Pages 197-226
  3. Methods

    1. Front Matter
      Pages 227-227
    2. Konstantinia Skreka, Michael Karbiener, Marek Zywicki, Alexander Hüttenhofer, Marcel Scheideler, Mathieu Rederstorff
      Pages 229-251
    3. Yoshinari Ando, A. Maxwell Burroughs, Mitsuoki Kawano, Michiel Jan Laurens de Hoon, Yoshihide Hayashizaki
      Pages 253-271
    4. Elizabeth L. Johnson, Eric J. Suh, Talia R. Chapman, Hilary A. Coller
      Pages 295-317
    5. Marc Hallier, Svetlana Chabelskaya, Brice Felden
      Pages 341-370
    6. Shijun Hu, Andrew Stephen Lee
      Pages 371-384
  4. Applications

    1. Front Matter
      Pages 385-385
    2. Russell C. Langan, John Mullinax, Manish Raiji, Itzhak Avital
      Pages 387-408

About this book

Introduction

Recent progress in high-throughput technologies and genome wide transcriptome studies have lead to a significant scientific milestone of discovering non-coding RNAs (ncRNAs) which spans through a major portion of the genome. These RNAs most often act as riboregulators, and actively participate in the regulation of important cellular functions at the transcriptional and/or post-transcriptional levels rather than simply being an intermediated messenger between DNA and proteins. As the appreciation for the importance of ncRNAs continues to emerge, it is also increasingly clear that these play critical roles in gene regulatory processes during development and differentiation. Further, regulatory RNAs are useful biomarkers for diagnosis of diseases. Hence these RNA regulators are essential to the development of therapeutics. This book on “Regulatory RNAs” offers a comprehensive view on our current understanding of these regulatory RNAs viz. siRNA, miRNA, piRNA, snoRNA, long non-coding RNA, small RNA etc. It addresses both the biogenesis and mechanism of action of regulatory RNAs with a primary focus on their annotation, experimental methodologies (microarray, next-gen sequencing etc.) for their discovery, computational tools for their prediction, and above all, applications of these revolutionary regulatory molecules in understanding biological systems and diseases, including therapeutics. This comprehensive volume is intended for readers with research or teaching interests in ncRNA biology and will provide a major information resource on current research in the fast-moving fields of RNA and gene expression regulation. Cutting-edge and concise, “Regulatory RNAs: Basics, Methods and Applications” promises to support vital research in the field of regulatory RNAs, ever-continuing to grow rapidly and gain increasing importance in basic and translational biology.

Keywords

non-coding RNAs regulatory RNAs small RNAs

Editors and affiliations

  • Bibekanand Mallick
    • 1
  • Zhumur Ghosh
    • 2
  1. 1., New York State Department of HealthWadsworth CenterNew YorkUSA
  2. 2.A.J.C. Bose Centenary Building, P-1/12, CIT Scheme - VII MBose InstituteKolkataIndia

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-22517-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 2012
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-22516-1
  • Online ISBN 978-3-642-22517-8
  • About this book