Stress Challenges and Immunity in Space

From Mechanisms to Monitoring and Preventive Strategies

  • Alexander Chouker

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Prelude

    1. Front Matter
      Pages 1-1
    2. Sarah Baatout, Alexander Choukèr, Ines Kaufmann, Nicola Montano, Siegfried Praun, Dominique de Quervain et al.
      Pages 5-8
  3. “Stress and Immunity” - Research: A Link Between Space and Earth

    1. Front Matter
      Pages 9-9
    2. Bruce S. McEwen, Ilia N. Karatsoreos
      Pages 11-29
    3. Lisa M. Christian, Ronald Glaser
      Pages 31-43
  4. Stress and Immune Allostasis in Space, from Brain to Immune Responses

    1. Front Matter
      Pages 45-45
    2. Nicola Montano, Eleonora Tobaldini, Alberto Porta
      Pages 71-86
    3. Mathias Steinach, Hanns-Christian Gunga
      Pages 87-106
    4. Daniela Hauer, Roland Toth, Gustav Schelling
      Pages 107-126
    5. Matthias Feuerecker, Alex P. Salam, Ines Kaufmann, André Martignoni, Alexander Choukèr
      Pages 141-153
    6. Boris Morukov, Marina Rykova, Eugenia Antropova
      Pages 155-164
    7. Brian Crucian, Clarence Sams
      Pages 165-175
    8. Manfred Thiel, Michail Sitkovsky, Alexander Choukèr
      Pages 177-185
    9. Oliver Ullrich, Cora S. Thiel
      Pages 187-202
    10. C. Mark Ott, Aurélie Crabbé, James W. Wilson, Jennifer Barrila, Sarah L. Castro, Cheryl A. Nickerson
      Pages 203-225
    11. Raymond P. Stowe, Duane L. Pierson, Satish K. Mehta
      Pages 227-237
    12. Marjan Moreels, Louis de Saint-Georges, Filip Vanhavere, Sarah Baatout
      Pages 239-260
  5. Preventive and Diagnostic Tools and Strategies

    1. Front Matter
      Pages 261-261
    2. Bernd Johannes, Berna van Baarsen
      Pages 269-277
    3. Michael Dolch, Siegfried Praun, Johannes Villiger, Alexander Choukèr, Gustav Schelling
      Pages 289-297
    4. Rob Van Houdt, Natalie Leys
      Pages 299-308
    5. Andreas Werner, Hanns-Christian Gunga
      Pages 309-326
    6. Marjan Moreels, Roel Quintens, Sarah Baatout
      Pages 345-356
  6. Preventive and Therapeutic Strategies

    1. Front Matter
      Pages 357-357
    2. Jean-Pol Frippiat, Martina Heer, Alexander Choukèr
      Pages 359-361
    3. Gro Mjeldheim Sandal, Gloria R. Leon
      Pages 363-372
    4. Vera Abeln, Stefan Schneider
      Pages 373-386
    5. Martina Heer, Natalie Baecker, Scott M. Smith, Sara R. Swart
      Pages 387-403
    6. Nathan Guéguinou, Matthieu Bascove, Jean-Pol Frippiat
      Pages 405-414
  7. Perspectives for Manned Space Exploration

  8. Back Matter
    Pages 461-469

About this book


Stress of either a psychological or a physical nature can activate and/or paralyse humans’ innate or adaptive immunity. However, adequate immunity is crucial to the maintenance of health on earth and in space. During space flight, human physiology and health are challenged by complex environmental stressors (confinement, gravitation, oxygen tension, radiation) which might be at their most pronounced during lunar or interplanetary missions. This book adopts an interdisciplinary approach in seeking to identify the impact of living conditions in space on the adaptation of the immune system. While other publications have addressed the physiological changes that occur during space flight, to the authors’ knowledge this is the first book specifically to analyze the complex interaction of living conditions in space, the immune system, and astronauts’ health. It is explained how such analysis of the consequences of stress for the immune system may help in preventing, diagnosing, and counteracting immune-related alterations in health on earth as well as in space.


Adaption Health monitoring Homeostasis Immune physiology

Editors and affiliations

  • Alexander Chouker
    • 1
  1. 1.Klinikum Großhadern, Klinik für Anästhesiologie undUniversitätsklinikum MünchenMünchenGermany

Bibliographic information