Modeling Fragile X Syndrome

  • Robert B. Denman

Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 54)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Ex Vivo Models

    1. Front Matter
      Pages 13-13
    2. Shelley Jacobs, Connie Cheng, Laurie C. Doering
      Pages 15-31
    3. Maija Castrén
      Pages 33-40
    4. Theodore J. Price, Ohannes K. Melemedjian
      Pages 41-59
    5. Stefan Kindler, Hans-Jürgen Kreienkamp
      Pages 61-80
  3. Non-Mouse Eukaryote Models

    1. Front Matter
      Pages 81-81
    2. Sean M. McBride, Aaron J. Bell, Thomas A. Jongens
      Pages 83-117
    3. Charles R. Tessier, Kendal Broadie
      Pages 119-156
    4. Abrar Qurashi, Xuekun Li, Peng Jin
      Pages 157-164
    5. Marc-Etienne Huot, Nicolas Bisson, Thomas Moss, Edouard W. Khandjian
      Pages 165-179
  4. Novel Mouse Models

    1. Front Matter
      Pages 199-199
    2. Abdeslem El Idrissi, Xin Yan, William L’Amoreaux, W. Ted Brown, Carl Dobkin
      Pages 201-221
    3. Susan M. Goebel-Goody, Paul J. Lombroso
      Pages 223-241
    4. Michael R. Hunsaker, Gloria Arque, Robert F. Berman, Rob Willemsen, Renate K. Hukema
      Pages 255-269
  5. The Human Model

    1. Front Matter
      Pages 271-271
    2. W. Ted Brown
      Pages 273-279

About this book

Introduction

The present book is an in-depth synopsis of recent advances in the fragile X field. The fragile X syndrome (FXS) is the most common form of inherited mental retardation, and the molecular-genetic basis of this syndrome has been the subject of extensive experimental scrutiny over the last two decades. This book covers the spectrum of current FXS research, ranging from Drosophila model systems via mouse models to clinical and psychiatric aspects. The volume also provides updates on FXS-related diseases such as the fragile X-associated tremor/ataxia syndrome. Significant progress in recent years, as highlighted here by some of the most eminent researchers in the field, are grounds for optimism that successful therapeutical approaches may be feasible in the not too distant future.

Keywords

Epigenetics FMR1 FMR1 Gene FXS Fragile X Syndrome Genetic disorder Inherited disease Stem cells

Editors and affiliations

  • Robert B. Denman
    • 1
  1. 1.New York State Institute for Basic ReseaStaten IslandUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-21649-7
  • Copyright Information Springer-Verlag Berlin Heidelberg 2012
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-21648-0
  • Online ISBN 978-3-642-21649-7
  • Series Print ISSN 0080-1844
  • Series Online ISSN 1861-0412
  • About this book