Modeling Fragile X Syndrome

  • Robert B. Denman

Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 54)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Ex Vivo Models

    1. Front Matter
      Pages 13-13
    2. Shelley Jacobs, Connie Cheng, Laurie C. Doering
      Pages 15-31
    3. Maija Castrén
      Pages 33-40
    4. Theodore J. Price, Ohannes K. Melemedjian
      Pages 41-59
    5. Stefan Kindler, Hans-Jürgen Kreienkamp
      Pages 61-80
  3. Non-Mouse Eukaryote Models

    1. Front Matter
      Pages 81-81
    2. Sean M. McBride, Aaron J. Bell, Thomas A. Jongens
      Pages 83-117
    3. Charles R. Tessier, Kendal Broadie
      Pages 119-156
    4. Abrar Qurashi, Xuekun Li, Peng Jin
      Pages 157-164
    5. Marc-Etienne Huot, Nicolas Bisson, Thomas Moss, Edouard W. Khandjian
      Pages 165-179
  4. Novel Mouse Models

    1. Front Matter
      Pages 199-199
    2. Abdeslem El Idrissi, Xin Yan, William L’Amoreaux, W. Ted Brown, Carl Dobkin
      Pages 201-221
    3. Susan M. Goebel-Goody, Paul J. Lombroso
      Pages 223-241
    4. Michael R. Hunsaker, Gloria Arque, Robert F. Berman, Rob Willemsen, Renate K. Hukema
      Pages 255-269
  5. The Human Model

    1. Front Matter
      Pages 271-271
    2. W. Ted Brown
      Pages 273-279
    3. Michael R. Tranfaglia
      Pages 281-295
    4. Randi Hagerman, Julie Lauterborn, Jacky Au, Elizabeth Berry-Kravis
      Pages 297-335
    5. Flora Tassone, Randi Hagerman
      Pages 337-357
  6. Missing Models

    1. Front Matter
      Pages 359-359
    2. Robert B. Denman
      Pages 361-383
  7. Back Matter
    Pages 385-390

About this book


The present book is an in-depth synopsis of recent advances in the fragile X field. The fragile X syndrome (FXS) is the most common form of inherited mental retardation, and the molecular-genetic basis of this syndrome has been the subject of extensive experimental scrutiny over the last two decades. This book covers the spectrum of current FXS research, ranging from Drosophila model systems via mouse models to clinical and psychiatric aspects. The volume also provides updates on FXS-related diseases such as the fragile X-associated tremor/ataxia syndrome. Significant progress in recent years, as highlighted here by some of the most eminent researchers in the field, are grounds for optimism that successful therapeutical approaches may be feasible in the not too distant future.


Epigenetics FMR1 FMR1 Gene FXS Fragile X Syndrome Genetic disorder Inherited disease Stem cells

Editors and affiliations

  • Robert B. Denman
    • 1
  1. 1.New York State Institute for Basic ReseaStaten IslandUSA

Bibliographic information