Numerical Methods for the Life Scientist

Binding and Enzyme Kinetics Calculated with GNU Octave and MATLAB

  • Heino Prinz

Table of contents

  1. Front Matter
    Pages i-ix
  2. Heino Prinz
    Pages 1-4
  3. Heino Prinz
    Pages 5-13
  4. Heino Prinz
    Pages 15-29
  5. Heino Prinz
    Pages 31-41
  6. Heino Prinz
    Pages 43-70
  7. Heino Prinz
    Pages 71-96
  8. Heino Prinz
    Pages 97-118
  9. Heino Prinz
    Pages 119-141
  10. Back Matter
    Pages 147-149

About this book

Introduction

Enzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michaelis-Menten enzyme kinetics, use plausible approximations, others, like Hill equations for dose-response curves, are outdated. Calculating realistic reaction schemes requires numerical mathematical routines which usually are not covered in the curricula of life science. This textbook will give a step-by-step introduction to numerical solutions of non-linear and differential equations. It will be accompanied with a set of programs to calculate any reaction scheme on any personal computer. Typical examples from analytical biochemistry and pharmacology can be used as versatile templates. When a reaction scheme is applied for data fitting, the resulting parameters may not be unique. Correlation of parameters will be discussed and simplification strategies will be offered.

Keywords

Enzyme kinetics advanced textbook binding kinetics biochemistry dose-response curves numerical solutions to reaction schemes

Authors and affiliations

  • Heino Prinz
    • 1
  1. 1.AG Biochemische AnalytikMPI für Molekulare PhysiologieDortmundGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-20820-1
  • Copyright Information Springer-Verlag Berlin Heidelberg 2011
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-20819-5
  • Online ISBN 978-3-642-20820-1
  • About this book