Maturation Phenomenon in Cerebral Ischemia V

Fifth International Workshop April 28–May 1, 2002 Banff, Alberta, Canada

  • Alastair M. Buchan
  • Umeo Ito
  • Fred Colbourne
  • Toshihiko Kuroiwa
  • Igor Klatzo
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-XX
  2. Role of Genetic Expression and Neuronal Apoptosis and/or Necrosis

    1. Front Matter
      Pages 1-1
    2. J. P. MacManus, M. Jian, E. Preston, J. Webster, B. Zurakowski
      Pages 3-12
    3. Y. Tang, A. Lu, B. J. Aronow, K. R. Wagner, F. R. Sharp
      Pages 13-36
    4. T. Kaido, Y. Kamada, A. Heimann, T. Nishioka, O. Kempski, D. Bartsch et al.
      Pages 37-41
    5. Josef Krieglstein, Dagmar Selke, Yuan Zhu, Susanne Klumpp
      Pages 43-51
    6. T. Sugawara, M. Ferrand-Drake, F. Yu, C. Maier, E. E. Hoyte, P. H. Chan
      Pages 53-61
    7. K.-A. Hossmann, R. Hata, K. Maeda, T. Trapp, G. Mies
      Pages 65-77
  3. Ischemic Infarction: Inflammation

  4. Clinical Trials/Neuroprotection

    1. Front Matter
      Pages 135-135
    2. P. A. Barber, B. Bruederlin, A. M. Buchan
      Pages 137-156
  5. Factors and Mechanisms Enhancing Susceptibility or Tolerance (Glia)

    1. Front Matter
      Pages 157-157
    2. N. Plesnila, E Ringel, F. Staub, E. Stohr, C. C. Chang, A. Baethmann
      Pages 167-175
    3. L. Neeb, K. Ruscher, U. Dirnagl, A. Meisel
      Pages 177-187
    4. U. Ito, T. Kuroiwa, S. Hanyu, Y. Hakamata, E. Kawakami, I. Nakano et al.
      Pages 189-196
    5. Francesco Orzi, Guiseppe Battaglia, Ferdinandio Nicoletti, Francesca Girardi, Carla Busceti, Francesco Fornai
      Pages 205-213
  6. Factors Modulating Neuronal Plasticity and the Course of Maturation Phenomenon in Cerebral Ischemia (Metabolic and Inflammatory Factors)

    1. Front Matter
      Pages 215-215
    2. Minoru Tomita, Yasuo Fukuuchi, Takahiro Amano, Norio Tanahashi, Marahiro Kobari, Yataka To-mita et al.
      Pages 245-250
    3. Masaru Kubota, Makoto Nakane, Tadayoshi Nakagomi, Hitoshi Nakayama, Akira Tamura, Harumi Hisaki et al.
      Pages 251-263
    4. V. Wee Yong, P. Larsen
      Pages 275-275
  7. Neurogenesis Stem Cell Activation — Repair and Plasticity

    1. Front Matter
      Pages 277-277
    2. K. Tanaka, S. Nogawa, D. Ito, S. Suzuki, T. Dembo, A. Kosakai et al.
      Pages 285-296
    3. Barbro B. Johansson, Mila Komitova, Ekaterina Perfilieva, Bengt Mattsson, Peter Eriksson
      Pages 297-308
  8. Abstract and Poster Presentations

    1. Front Matter
      Pages 309-309
    2. T. Jover, H. Tanaka, A. Calderone, K. Oguro, M. V. L. Bennett, A. M. Etgen et al.
      Pages 311-311
    3. H. Yanamoto, I. Nagata, J.-H. Xue, Z.-W. Zhang, K. Murao, K. Iihara et al.
      Pages 321-322
    4. Natalie Cooper, P. Vandenberg, S. Cooper, Jeffrey Kleim
      Pages 325-325
    5. I. T. Sutcliffe, H. Smith, J. S. Hutchison, D. B. Stanimirovic
      Pages 327-329
    6. M. Qiao, P. Latta, R. Buist, S. Bascaramurty, T. Foniok, E. Mckenzie et al.
      Pages 331-332
    7. J.-H. Xue, H. Yanamoto, I. Nagata, Z.-W. Zhang, H. Kikuchi
      Pages 333-334
    8. M. Kubota, M. Nakane, T. Nakagomi, A. Tamura, H. Hisaki, N. Ueta
      Pages 335-336

About these proceedings


The Maturation Phenomenon, first described by Ito et al. in 1975, refers to post­ ischemic changes that develop hours or days after an ischemic insult. The delayed neuronal death of CAl pyramidal cells of the hippocampus is a classic example. The report of the phenomenon boosted research in the field, as it became evi­ dent that ischemic damage is not a sudden event but a process potentially suscep­ tible to therapeutic intervention. In September 1990, Ito and collaborators organized the First International Sym­ posium on "Maturation Phenomenon in Cerebral Ischemia" which was held in To­ kyo, Japan. The Second Symposium was organized in Tokyo, Japan in March/April 1996. The Third Symposium was held in Pozzilli, Italy in April 1998 and the Fourth Symposium was held in New Orleans, Louisiana, USA in October/Novem­ ber 1999. This book contains the presentations of the Fifth International Workshop on Maturation Phenomenon in Cerebral Ischemia held at the Rimrock Resort Ho­ tel in Banff, Alberta, Canada on April 28-May 1, 2002. It outlines the present sta­ tus of investigations and provides further stimulation for research in this field. The Maturation Phenomenon represents a continuing struggle for survival be­ tween the acceleration of tissue or neuronal death and the activation of defense mechanisms leading to neuronal recovery. The elucidation of these mechanisms is important for developing the ability to manipulate them during a long-lasting "therapeutic window".


MR imaging brain cerebral ischemia depression forebrain hypoxia neurons neuroprotection rehabilitation stroke tumor

Editors and affiliations

  • Alastair M. Buchan
    • 1
  • Umeo Ito
    • 2
  • Fred Colbourne
    • 3
  • Toshihiko Kuroiwa
    • 4
  • Igor Klatzo
    • 5
  1. 1.Office of Stroke ResearchFoothills Medical CentreCalgaryCanada
  2. 2.Department of NeurosurgeryMusashino Red Cross HospitalTokyoJapan
  3. 3.Department of PsychologyUniversity of AlbertaEdmontonCanada
  4. 4.Department of Neuropathology Medical Research InstituteTokyo Medical and Dental UniversityTokyoJapan
  5. 5.Laboratory of Neuropathology and Neuroanatomical Sciences, NINDSNational Institutes of HealthBethesdaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2004
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-40874-1
  • Online ISBN 978-3-642-18713-1
  • Buy this book on publisher's site