Invertebrate Cytokines and the Phylogeny of Immunity

Facts and Paradoxes

  • Alain Beschin
  • Werner E. G. Müller

Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 34)

Table of contents

  1. Front Matter
    Pages I-XI
  2. E. Ottaviani, D. Malagoli, A. Franchini
    Pages 1-25
  3. D. L. Bodian, S. Leung, H. Chiu, S. Govind
    Pages 27-46
  4. H. Wajant, P. Scheurich
    Pages 47-72
  5. L. Parker, D. G. Stathakis, K. Arora
    Pages 73-101
  6. W. E. G. Müller, M. Wiens, I. M. Müller, H. C. Schröder
    Pages 103-143
  7. Back Matter
    Pages 183-184

About this book


Based on the assumption that invertebrates as well as vertebrates possess factors regulating hematopoiesis, response to infection or wounding, studies dealing with the evolution of immunity have focused on the isolation and characterization of putative cytokine-related molecules from invertebrates. Until recently, most of our knowledge of cytokine- and cytokine receptor-like molecules in invertebrates has relied on functional assays and similarities at the physicochemical level. As such, a phylogenetic relationship between invertebrate cytokine-like molecules and invertebrate counterparts could not be convincingly demonstrated.
In the present book, recent studies demonstrating cytokine-like activities and related signaling pathways in invertebrates are critically reviewed, focusing on findings from molecular biology and taking advantage of the completion of the genome from the fly Drosophila and the worm Caenorhabditis elegans.


Drosophila biology cytokine cytokines evolution genome hematopoiesis immunity infection invertebrates molecular biology phylogeny receptor stem cell stem cells

Editors and affiliations

  • Alain Beschin
    • 1
  • Werner E. G. Müller
    • 2
  1. 1.Department of Cellular and Molecular Interactions Flemish Interuniversity Institute for BiotechnologyFree University of Brussels (VIB-VUB)BrusselsBelgium
  2. 2.Institut für Physiologische Chemie Abt. Angewandte MolecularbiologieJohannes Gutenberg-UniversitätMainzGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2004
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-62236-6
  • Online ISBN 978-3-642-18670-7
  • Series Print ISSN 0079-6484
  • Buy this book on publisher's site