Acute Leukemias VIII

Prognostic Factors and Treatment Strategies

  • T. Büchner
  • W. Hiddemann
  • B. Wörmann
  • G. Schellong
  • J. Ritter
  • U. Creutzig
Conference proceedings

Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 40)

Table of contents

  1. Front Matter
    Pages I-XXVII
    PDF

  2. Leukemia Cell Biology Monitoring and Prognosis

    1. Front Matter
      Pages 1-1
      PDF
    2. Mechanisms of Chromosomal Translocation Breakpoints
      P. D. Aplan, M. Stanulla
      Pages 3-10
    3. Hematologic Malignancies Following Organ Transplantation
      H. E. Wilczek, C. Brattström
      Pages 11-14
    4. Molecular Cytogenetic Characterization of a Critical Region in Bands 7q35-q36 Commonly Deleted in Malignant Myeloid Disorders
      K. DÖhner, U. Hehmann, J. Brown, C. Hetzel, J. Stewart, G. Lowther et al.
      Pages 15-19
    5. Molecular Characterization of the Translocation (10;11)(p13;q14): MLLandCALMare Fused toAF10in Morphologically Different Subsets of Acute Leukemia
      M. H. Dreyling, K. Schrader, V. Muschinsky, C. Fonatsch, B. Schlegelberger, D. Haase et al.
      Pages 20-26
    6. MLL-Duplications are Rare and Associated with Poor Prognosis in Acute Myeloid Leukemia
      S. Schnittger, U. Kinkelin, C. Schoch, D. Haase, T. Haferlach, T. BÜchner et al.
      Pages 27-33
    7. Real-Time RT-PCR for the Detection and Quantification of AML1/MTG8 Fusion Transcripts in Patients with t(8;21) Positive AML
      J. Krauter, M. P. Wattjes, S. Nagel, O. Heidenreich, U. Krug, S. Kafert et al.
      Pages 34-39
    8. Combined Cytogenetic, FISH and RT-PCR Technique in Detection of t(15;17) and Monitoring of Minimal Residual Disease in Acute Promyelocytic Leukemia
      Yu. V. Olshanskaya, I. A. Demidova, N. G. Tiurina, A. I. Udovitchenko, L. A. Vodinskaia, A. B. Sudarikov et al.
      Pages 40-43
    9. RT-PCR in Diagnostics and Monitoring of Acute Myeloid
      S. Schnittger, C. Schoch, F. Griesinger, T. Büchner, H. Löffler, T. Haferlach et al.
      Pages 44-48
    10. Chromosome Aberrations in Primary and Secondary Acute Myeloblastic Leukemia (AML)
      O. Haus, M. Czarnecka, S. Kotlarek-Haus, K. Kuliczkowski, E. Duszenko, I. Makowska
      Pages 49-53
    11. Are there Two Main Categories of de Novo Acute Myeloid Leukemias with a Normal Karyotype?
      P. Lemež, J. Gáliková, T. Haas
      Pages 54-60
    12. Asynchronous Expression of AC133 on CD34-Negative Leukemic Blast Cells in Childhood B-Cell Precursor ALL
      G. Baersch, M. Baumann, J. Ritter, H. JÜRgens, J. Vormoor
      Pages 61-63
    13. Expression of AC133 in Childhood Acute Leukemia
      U. Ebener, S. Wehner, A. Brinkmann, E. Niegemann, B. Kornhuber
      Pages 64-71
    14. CD10 Expression in T-Lineage Adult Acute Lymphoblastic Leukemia
      X. Thomas, C. Charrin, J.-P. Magaud, D. Fière
      Pages 72-77
    15. Acute Lymphoblastic Leukemia in Childhood with an Unusual Immunophenotype (CD7 +/CD56 +/CD33 +)
      U. Ebener, S. Wehner, E. Niegemann, B. Kornhuber
      Pages 78-84
    16. Expression of IGFBP-rP2 / CTGF is Specific for Malignant Lymphoblasts of Children with Acute Lymphoblastic Leucemia (ALL)
      P. Vorwerk, J. Elsner, K. Mohnike, Y. Oh, R. G. Rosenfeld, U. Mittler
      Pages 85-88
    17. NM23-H1 Protein Expression as a New Prognostic Factor in Acute Lymphoblastic Leukemia
      B. Höchsmann, E. Müller, G. Heil, N. Frickhofen, L. Bergmann
      Pages 89-95
    18. Monitoring of Wilms’ Tumor Gene Transcription in Leukemia Patients
      E. Niegemann, S. Wehner, D. Schwabe, U. Ebener
      Pages 96-99
    19. Effect of Mutationally Activated Ras on the Ras to MAP Kinase Signaling Pathway and Growth Inhibition of Myeloid Leukemia Cells by Inhibitors of the MAP Kinase Cascade
      Ch. W. M. Reuter, M. A. Morgan, L. Bergmann
      Pages 100-108

About these proceedings

Introduction

Since 1987 Acute Leukemias (AL) has regularly reported on the state of the art in the rapidly growing, successful and exciting field of biology and management of these diseases. In this volume large multicenter clinical trials again form the solid basis for the investigation of leukemic cell biology, the detection of biologic subgroups, their differential response to alternative treatment strategies and the further development of therapy. In particular, this volume addresses mechanisms of chromosomal translocations and transcription factors, risk-adapted treatment strategies, differentiation therapy, secondary AL, special aspects in older patients, and adoptive immunotherapy. Besides the antileukemic approaches, supportive treatment with new antimicrobial substances and growth factors is updated. As a forum of worldwide activities in the field of AL this volume contains both exhaustive overviews on major clinical issues and preliminary data and hypotheses not previously published.

Keywords

apoptosis cell cell biology chemotherapy clinical trial diagnostics hematopoietic stem cell immunotherapy infection leukemia lymphocytes oncology stem cell transplantation transplantation tumor

Editors and affiliations

  • T. Büchner
    • 1
  • W. Hiddemann
    • 2
  • B. Wörmann
    • 3
  • G. Schellong
    • 4
  • J. Ritter
    • 4
  • U. Creutzig
    • 4
  1. 1.Department of Internal Medicine AGermany
  2. 2.Department of Internal Medicine IIIUniversity Hospital Großhadern Ludwig-Maximilians-UniversityMünchenGermany
  3. 3.Dept. of Internal MedicineUniversity of GöttingenGöttingenGermany
  4. 4.Department of PediatricsUniversity of MünsterMünsterGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-18156-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 2001
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-62109-3
  • Online ISBN 978-3-642-18156-6
  • Series Print ISSN 0440-0607
  • Buy this book on publisher's site