Heart Rate and Rhythm

Molecular Basis, Pharmacological Modulation and Clinical Implications

  • Onkar N. Tripathi
  • Ursula Ravens
  • Michael C. Sanguinetti

Table of contents

  1. Front Matter
    Pages i-xxii
  2. Normal Cardiac Rhythm and Pacemaker Activity

    1. Front Matter
      Pages 1-1
    2. Onkar Nath Tripathi
      Pages 3-31
    3. Andrea Barbuti, Annalisa Bucchi, Raffaella Milanesi, Georgia Bottelli, Alessia Crespi, Dario DiFrancesco
      Pages 59-81
    4. Ronald Wilders, Antoni C. G. van Ginneken, Arie O. Verkerk
      Pages 101-117
    5. T. Alexander Quinn, Rebecca A. Bayliss, Peter Kohl
      Pages 133-151
  3. Modeling

    1. Front Matter
      Pages 153-153
    2. Jonathan D. Moreno, Colleen E. Clancy
      Pages 175-194
  4. Cardiac Development and Anatomy

    1. Front Matter
      Pages 195-195
    2. Huamin Liang, Michael Reppel, Ming Tang, Jürgen Hescheler
      Pages 197-209
    3. Halina Dobrzynski, Oliver Monfredi, Ian D. Greener, Andrew Atkinson, Shin Inada, Mary-Anne Taube et al.
      Pages 211-230
    4. C. H. Orchard, F. Brette, A. Chase, M. R. Fowler
      Pages 255-266
  5. Mechanisms of Acquired Arrhythmia

    1. Front Matter
      Pages 267-267
    2. Rupamanjari Majumder, Alok Ranjan Nayak, Rahul Pandit
      Pages 269-282
    3. Wen Dun, Henk ter Keurs, Penelope A. Boyden
      Pages 305-322
    4. Yasser Abdellatif, Vijayan Elimban, Delfin Rodriguez-Leyva, Naranjan S. Dhalla
      Pages 323-335
    5. Yasser Abdellatif, Adriana Adameova, Naranjan S. Dhalla
      Pages 337-349
  6. Mechanisms of Inherited Arrhythmia

    1. Front Matter
      Pages 385-385
    2. Nicola Monteforte, Carlo Napolitano, Raffaella Bloise, Silvia G. Priori
      Pages 387-408
    3. Jules C. Hancox, Mark J. McPate, Aziza El Harchi, Rona S. Duncan, Chris E. Dempsey, Harry J. Witchel et al.
      Pages 431-449
    4. Hjalti Gudmundsson, Francis Jareczek, Peter J. Mohler
      Pages 461-472
    5. Saagar Mahida, Michiel Rienstra, Moritz F. Sinner, Steven A. Lubitz, Patrick T. Ellinor, Stefan Kääb
      Pages 485-499
  7. Role of Specific Channels and Transporters in Arrhythmia

    1. Front Matter
      Pages 501-501
    2. Stefan Dhein, Joanna Jozwiak, Anja Hagen, Thomas Seidel, Anna Dietze, Aida Salameh et al.
      Pages 503-524
    3. András Tóth, András Varró
      Pages 543-561
    4. Tanya L. Butler, David S. Winlaw
      Pages 581-595
  8. Drugs and Cardiac Arrhythmia

    1. Front Matter
      Pages 597-597
    2. Michael C. Sanguinetti, Matthew Perry
      Pages 611-625
    3. Nathalie Strutz-Seebohm, Guiscard Seebohm
      Pages 655-668
  9. Back Matter
    Pages 669-678

About this book


Pathological heart rhythms are a major health issue. In this book experts from various fields provide an important context for understanding the complicated molecular and cellular mechanisms that underlie normal and pathophysiological cardiac rhythms. Individual chapters cover a full range of topics, including the ionic basis of pacemaking, the role of specific channels and transporters in sinoatrial node pacemaking, altered intracellular Ca2+ handling in response to disease, computer modeling of the action potentials of pacemaker and working cardiomyocytes, genetic and molecular basis of inherited arrhythmias and a review of established and novel antiarrhythmic agents. Due to the key importance of the specialized pacemaker cells and tissue (sinoatrial and atrioventricular nodes) in maintaining heart rate and rhythm, special emphasis is placed on the peculiar electrophysiology of these cells.


Action potentials Arrhythmogenesis Atrioventricular junction Cardiac pacemaker Intracellular Ca Ion channels Myocard Purkinje fibres

Editors and affiliations

  • Onkar N. Tripathi
    • 1
  • Ursula Ravens
    • 2
  • Michael C. Sanguinetti
    • 3
  1. 1.Life Sciences AcademyLucknowIndia
  2. 2.Medizinische Fakultät, Inst. für Pharmakologie u. ToxikologieTU DresdenDresdenGermany
  3. 3.Cardiovascular Research &, Training Inst. (CVRTI)University of UtahSalt Lake CityUSA

Bibliographic information