Brain, Behavior and Epigenetics

  • Arturas Petronis
  • Jonathan Mill

Part of the Epigenetics and Human Health book series (EHH)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Schahram Akbarian, Iris Cheung, Caroline Connor, Mira Jakovcevski, Yan Jiang
    Pages 1-21
  3. Dennis R. Grayson, Marija Kundakovic, Ying Chen, Erbo Dong, Alessandro Guidotti
    Pages 23-40
  4. Benoit Labonté, Gustavo Turecki
    Pages 49-70
  5. Mary Perrin, Karine Kleinhaus, Mark Opler, Julie Messinger, Dolores Malaspina
    Pages 71-96
  6. Wim Veling, L. H. Lumey, Bas Heijmans, Ezra Susser
    Pages 97-118
  7. Anthony R. Isles, Lawrence S. Wilkinson
    Pages 169-184
  8. Frances A. Champagne, James P. Curley
    Pages 185-208
  9. Marcel A. Estevez, Ted Abel
    Pages 267-285
  10. Johannes M. H. M. Reul, Andrew Collins, María Gutièrrez-Mecinas
    Pages 287-300
  11. Back Matter
    Pages 301-317

About this book

Introduction

Despite significant progress in molecular epigenetic research and its enormous potential, there are still considerable challenges to overcome before we can fully understand the role of epigenetic processes in brain function and behavior. For instance, what comprises a ‘normal’ brain epigenome and what is the degree of region- and cellular-specificity of epigenetic landscapes in the brain? How do the multiple layers of epigenetic information interact and change over time? How common is meiotic epigenetic heritability and what role it may play in complex psychiatric disease? To what extent is the epigenome plastic and malleable in response to environmental influences? This volume demonstrates that such questions can now be explored in an experimental molecular biology laboratory. While the community is only just starting to acknowledge the importance of epigenetic processes in the brain, there is no doubt that numerous breakthrough discoveries in brain and behavioral epigenetics will be made in the decades to come.

Keywords

GABA acetylation attachment theory bipolar disorder chromatin remodelling cognitive disorder depression genomic imprinting histone modifications memory formation phosphorylation schizophrenia suicide transgenerational inheritance twin studies x-inactivation

Editors and affiliations

  • Arturas Petronis
    • 1
  • Jonathan Mill
    • 2
  1. 1., The Krembil Family Epigenetics LaboratorCentre for Addiction and Mental HealthTorontoCanada
  2. 2., Institute of PsychiatryKing's College LondonLondonUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-17426-1
  • Copyright Information Springer-Verlag Berlin Heidelberg 2011
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-17425-4
  • Online ISBN 978-3-642-17426-1
  • About this book