The Extracellular Matrix: an Overview

  • Robert P. Mecham

Part of the Biology of Extracellular Matrix book series (BEM)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Jürgen Engel, Matthias Chiquet
    Pages 1-39
  3. Jielin Xu, Deane Mosher
    Pages 41-75
  4. David E. Birk, Peter Brückner
    Pages 77-115
  5. Jeffrey H. Miner
    Pages 117-145
  6. Thomas N. Wight, Bryan P. Toole, Vincent C. Hascall
    Pages 147-195
  7. Renato V. Iozzo, Silvia Goldoni, Agnes D. Berendsen, Marian F. Young
    Pages 197-231
  8. Dirk Hubmacher, Dieter P. Reinhardt
    Pages 233-265
  9. Beth A. Kozel, Robert P. Mecham, Joel Rosenbloom
    Pages 267-301
  10. Herbert M. Kagan, Faina Ryvkin
    Pages 303-335
  11. Marion A. Cooley, W. Scott Argraves
    Pages 337-367
  12. David D. Roberts, Lester F. Lau
    Pages 369-413
  13. Back Matter
    Pages 415-425

About this book

Introduction

Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling.

This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment.  Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Keywords

Basement membrane Cell adhesion Collagen Elastin Fibronectin Microfibrils Thrombospondin

Editors and affiliations

  • Robert P. Mecham
    • 1
  1. 1.School of Medicine, Dept. Cell Biology & PhysiologyWashington UniversitySt. LouisUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-16555-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 2011
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-16554-2
  • Online ISBN 978-3-642-16555-9
  • About this book