Long Non-Coding RNAs

  • Durdica Ugarkovic

Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 51)

Also part of the Marine Molecular Biotechnology book sub series (volume 51)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Radha Raman Pandey, Chandrasekhar Kanduri
    Pages 1-27
  3. Cristina Gontan, Iris Jonkers, Joost Gribnau
    Pages 43-64
  4. Rajika Arora, Catherine M. C. Brun, Claus M. Azzalin
    Pages 65-94
  5. Claire Vourc’h, Giuseppe Biamonti
    Pages 95-118
  6. Audrey Berger, Katharina Strub
    Pages 119-146
  7. S. Kiran Koya, Victoria H. Meller
    Pages 147-160
  8. Željka Pezer, Josip Brajković, Isidoro Feliciello, Đurđica Ugarković
    Pages 161-178
  9. Virginie Jouannet, Martin Crespi
    Pages 179-200
  10. Back Matter
    Pages 201-205

About this book

Introduction

Long non-coding RNAs (lncRNAs), tentatively defined as ncRNAs of more than two hundred nucleotides in length, are characterized by the complexity and diversity of their sequences and mechanisms of action. Based on genome-wide studies, more than 3,300 of them exist, but to date only the limited number of functional lncRNAs have been identified and characterized. Nonetheless, lncRNAs have emerged as key molecules involved in the control of transcriptional and posttranscriptional gene regulatory pathways. They take part in the recruitment of chromatin modifying complexes and regulate splicing, localization, stability and translation of the target mRNAs.

This book provides an overview of the rapidly advancing field of long ncRNAs, describing the epigenetic and non-epigenetic mechanisms by which they regulate various biological functions in model systems, from yeast to mammals. The role of ncRNAs in sex chromosome dosage compensation in flies and mammals is described, as well as their role in centromere and telomere biology. Long non-coding RNAs involved in environmental stress response and development are presented and their mechanisms of action discussed.

Keywords

gene regulation lncRNAs long non-coding RNAs non-coding RNAs transcription

Editors and affiliations

  • Durdica Ugarkovic
    • 1
  1. 1.Center for Marine ResearchRuder Boskovic InstituteZagrebCroatia

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-16502-3
  • Copyright Information Springer-Verlag Berlin Heidelberg 2011
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-16501-6
  • Online ISBN 978-3-642-16502-3
  • Series Print ISSN 0079-6484
  • About this book