Footmarks of Innate Immunity in the Ovary and Cytokeratin-Positive Cells as Potential Dendritic Cells

  • Katharina┬áSpanel-Borowski
Part of the Advances in Anatomy, Embryology and Cell Biology book series (ADVSANAT, volume 209)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Katharina Spanel-Borowski
    Pages 1-6
  3. Katharina Spanel-Borowski
    Pages 7-15
  4. Katharina Spanel-Borowski
    Pages 17-34
  5. Katharina Spanel-Borowski
    Pages 45-76
  6. Katharina Spanel-Borowski
    Pages 77-82
  7. Katharina Spanel-Borowski
    Pages 83-85
  8. Katharina Spanel-Borowski
    Pages 87-88
  9. Back Matter
    Pages 89-110

About this book

Introduction

The cyclic ovary can be seen as a site of tissue damage, repair and precisely controlled tissue homeostasis, as long ovulation and luteolysis can be compared with acute and chronic inflammation. Innate immunity appears to be a powerful force in the endocrine system, representing a novel concept. In this monograph, remarkable evidence is given for the immune-privileged ovary being an implant on the chicken chorioallantoic membrane with an areactive mesenchyme. Mild to severe tissue damages due to follicular atresia, follicular rupture, or intraovarian oocyte release do no lasting harm. The most exciting part relates to the analysis of cytokeratin-positive (CK+) cells, comparing the fate mapping of this cell type from the fetal ovary to the adult organ. Findings on toll-like receptor 4 regulation and interferon-gamma-dependent positive effects indicate that CK+ cells from human preovulatory follicles and bovine corpora lutea have similarities with nonlymphoid dendritic cells, a discovery that has the makings of a top story in basic and clinical research on the ovary.

Keywords

Chick chorioallantoic membrane Corpus luteum Fetal ovary Follicular atresia Granulosa cells Intra-ovarian oocyte release Lox-1 receptor Microvascular endothelial cells Ovulation Oxidative stress Preovulatory follicle Toll-like receptor 4

Authors and affiliations

  • Katharina┬áSpanel-Borowski
    • 1
  1. 1., Institute of AnatomyUniversity of LeipzigLeipzigGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-16077-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 2011
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-642-16076-9
  • Online ISBN 978-3-642-16077-6
  • Series Print ISSN 0301-5556