Epigenetics and Human Reproduction

  • Sophie Rousseaux
  • Saadi Khochbin

Part of the Epigenetics and Human Health book series (EHH)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Medical Aspects and Questions Raised on the Molecular Basis of Epigenome Involvement in Reproduction

    1. Front Matter
      Pages 1-1
    2. Kristian Almstrup, Olga Mlynarska, Ewa Rajpert-De Meyts
      Pages 19-44
    3. Rafael Oliva, Sara de Mateo
      Pages 45-83
  3. Fundamental Aspects of Genome and Epigenome Reprogramming During Gametogenesis

    1. Front Matter
      Pages 97-97
    2. P. Barthès, J. Buard, B. de Massy
      Pages 119-156
    3. P. de Boer, M. de Vries, S. Gochhait
      Pages 187-212
    4. Juan Ausió, Laurence R. Brewer, Lindsay Frehlick
      Pages 213-230
    5. Adrian E. Platts, Claudia Lalancette, Stephen A. Krawetz
      Pages 231-258
  4. Re-organization of Nuclear Compartments During Gametogenesis

    1. Front Matter
      Pages 259-259
    2. Olga Mudrak, Irina Zalenskaya, Andrei Zalensky
      Pages 261-277
    3. Manfred Alsheimer, Daniel Jahn, Sabine Schramm, Ricardo Benavente
      Pages 279-288
  5. Fundamental Aspects of Gene Expression Regulation During Gametogenesis

    1. Front Matter
      Pages 289-289
    2. Ippei Nagamori, Adam Cruickshank, Paolo Sassone-Corsi
      Pages 311-328
    3. David Miller
      Pages 329-353
  6. Back Matter
    Pages 355-372

About this book


Epigenetics is a rapidly expanding field in medical and biological research which concerns heritable traits that are not attributable to changes in the DNA sequence. Epigenetic mechanisms play key roles in many biological processes, and it has become clear that their disruption can gives rise to diverse pathologies in humans. Edited by preeminent experts, Sophie Rousseaux and Saadi Khochbin, this volume in the ‘Epigenetics and Human Health’ series discusses the role of epigenetics in human reproduction. The book presents epigenetic transitions that are important at defined stages of gametogenesis and during meiosis. Several of the sixteen chapters written by experts in the field cover fundamental concepts discovered through cellular and biochemical work and from research on animal models. In other chapters, key examples are provided of how disruption of these mechanisms affects germ cell development and fertility, and contributes to the germinal cancers. Finally, the book discusses how in vitro manipulation and culture in assisted reproduction can epigenetically perturb germ cells, and how this can trigger disease phenotypes in the next generation. Conceived towards advanced students, medical professionals and research scientists, this is the first comprehensive textbook on this topic that will serve as a valuable reference during the years to come


PGC reprogramming chromosome synapsis fertility gametogenesis germ cell development germinal cancers in vitro manipulation mammalian meiosis reproductive cloning spermatogenesis testis dysgenesis syndromes

Editors and affiliations

  • Sophie Rousseaux
    • 1
  • Saadi Khochbin
    • 2
  1. 1.INSERM U309, Labo. Biologie Moléculaire etInstitut Albert BonniotLa Tronche CXFrance
  2. 2.INSERM U309, Labo. Biologie Moléculaire etInstitut Albert BonniotLa Tronche CXFrance

Bibliographic information