Novel Insights into Adipose Cell Functions

  • Yves Christen
  • Karine Clément
  • Bruce M. Spiegelman

Table of contents

  1. Front Matter
    Pages i-xi
  2. A. L. Dinel, C. Kolditz, D. Langin
    Pages 21-43
  3. Paul Trayhurn, Fátima Pérez de Heredia, Bohan Wang, I. Stuart Wood
    Pages 45-60
  4. Kai Sun, Philipp E. Scherer
    Pages 67-75
  5. Evan D. Rosen
    Pages 101-110
  6. Rudolph L. Leibel, Michael Rosenbaum
    Pages 121-133
  7. Back Matter
    Pages 145-147

About this book

Introduction

Obesity is considered as top at risk condition in the world and it is mandatory to identify the physiopathological causes involved in adipose tissue enlargement and related metabolic and cardiovascular health disorders. Environmental, behavioural, genetic, epigenetic and multiple biological factors interact to cause obesity. In this context adipose tissue depots have been under focus in the last decades and pivotal concepts have emerged from the studies of their complex biology. While the white adipose tissue (WAT) is the main energy repository in the body (mobilizing fatty acids according to body needs) thanks to white adipocyte properties, WAT is also a multicellular organ communicating with other body organs (brain, muscles, liver, pancreas, heart, vessels, etc…) via complex networks of endocrine signals. The discovery of leptin in 1994 led to recognize WAT as a master organ at the crossroad of a myriad of physiological interactions to control food intake, energy balance, glucose and lipid metabolism, immunity and reproduction. The phenotype, amount and biology of each WAT component are profoundly altered in human obesity. Adipose plasticity also accounts for the extraordinary capacity of adipose precursors to differentiate into functional cardiomyocytes, osteoblasts, haematopoietic and neural cells, a convenient property for regenerative medicine. Finally, while initially thought to exert a negligible role in humans, the discovery of brown adipose tissue in adults stimulates a novel interest for this tissue with high capacity to oxidize fatty acids

Keywords

Regulation adipose tissue dysfunction anti-obesity therapy brown adipose tissue dynamics leptin tissue white adipose issue

Editors and affiliations

  • Yves Christen
    • 1
  • Karine Clément
    • 2
  • Bruce M. Spiegelman
    • 3
  1. 1.Fondation IPSENBoulogne-Billancourt CedexFrance
  2. 2., Endocrinology and Nutrition DepartmentPitié Salpetrière HospitalParisFrance
  3. 3.and the Harvard Medical SchoolDana Farber Cancer InstituteBostonUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-13517-0
  • Copyright Information Springer-Verlag GmbH Berlin Heidelberg 2010
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-13516-3
  • Online ISBN 978-3-642-13517-0
  • Series Print ISSN 1861-2253
  • About this book