Cell Entry by Non-Enveloped Viruses

  • John E.┬áJohnson

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 343)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Umesh Katpally, Thomas J. Smith
    Pages 23-41
  3. Tobias J. Tuthill, Elisabetta Groppelli, James M. Hogle, David J. Rowlands
    Pages 43-89
  4. Pranav Danthi, Kristen M. Guglielmi, Eva Kirchner, Bernardo Mainou, Thilo Stehle, Terence S. Dermody
    Pages 91-119
  5. Matthew Baker, B. V. Venkataram Prasad
    Pages 121-148
  6. Billy Tsai, Mengding Qian
    Pages 177-194
  7. Jason G. Smith, Christopher M. Wiethoff, Phoebe L. Stewart, Glen R. Nemerow
    Pages 195-224
  8. Back Matter
    Pages 225-229

About this book


Non enveloped viruses constitute an important class of medically significant pathogens. They encode their proteins in single (ss) and double strand (ds) RNA and DNA genomes and display a variety of sizes and structures. In this volume experts in the field provide up to date descriptions of many characteristics associated with the ssRNA noda, picorna and calciviruses, the dsRNA reo and rotaviruses, the ssDNA parvoviruses and the dsDNA polyoma and adenoviruses. While many aspects of these viruses have been addressed previously, this volume specifically focuses on the issue of their entry into cells, with particular attention to the translocation of the viral genome through a membrane, without the aid of inter-membrane fusion that is common and reasonably well understood in enveloped viruses. Sufficient detail has been revealed in most of the viruses discussed in this volume to establish a credible argument for convergent evolution. A variety of mechanisms are described to generate and tightly control the exposure of a fusion-like peptide or an entire gene product that facilitates membrane permeation and genome delivery into the cytoplasm and, for the DNA viruses, the nucleus. Since there is no viral membrane to fuse with the cellular membrane, the events at this interface are different from those associated with enveloped viruses and with the various fusion events associated with normal cellular function. Thus, while the factors critical for this process to occur have been well established for many of these viruses, a specific mechanism for genome penetration is yet to be determined. We believe that this volume will provide a reference of enduring value for the non enveloped virus field and our hope is that the focus on entry and genome translocation across a cellular membrane will stimulate new ideas and mechanistic studies of this critically important process.


AdV pathogenesis Calicivirus Flock House Virus Nodavirus Parvovirus capsids Poliovirus Polyomavirus Reovirus Rotavirus Viruses

Editors and affiliations

  • John E.┬áJohnson
    • 1
  1. 1.Dept. Molecular BiologyScripps Research InstituteLa JollaUSA

Bibliographic information