Combating Fungal Infections

Problems and Remedy

  • Iqbal Ahmad
  • Mohammad Owais
  • Mohammed Shahid
  • Farrukh Aqil

Table of contents

  1. Front Matter
    Pages i-xx
  2. Ricardo Araujo, Cidália Pina-Vaz, Acácio Gonçalves Rodrigues
    Pages 1-19
  3. Mohd Sajjad Ahmad Khan, Iqbal Ahmad, Farrukh Aqil, Mohd Owais, Mohd Shahid, Javed Musarrat
    Pages 21-45
  4. Jose L. Blanco, Marta E. Garcia
    Pages 47-70
  5. Shamim Ahmad, Mohd Sajjad Ahmad Khan, Fohad Mabood Hussain, Iqbal Ahmad
    Pages 71-97
  6. Vassilios Fanos, Marco Zaffanello, Laura Cuzzolin, Luigi Cataldi
    Pages 109-124
  7. Ricardo Araujo, Ana Espinel-Ingroff
    Pages 125-145
  8. Mohammad Shahid, Iqbal Ahmad, Abida Malik, Noor Jahan, Trivendra Tripathi
    Pages 173-211
  9. Iqbal Ahmad, Mohd Sajjad Ahmad Khan, Maryam Zahin, Mohd Owais, Mohd Shahid, Zafar Mehmood et al.
    Pages 213-240
  10. Rafael Zaragoza, Javier Pemán, Miguel Salavert, Amparo Solé, Isidro Jarque, Emilio Monte et al.
    Pages 241-272
  11. Mohammad Owais, Mairaj Ahmed Ansari, Iqbal Ahmad, Qamar Zia, Gerald Pierard, Arun Chauhan
    Pages 347-371
  12. Mohammad Shahid, Trivendra Tripathi, Nancy Khardori, Anwar Huq, Iqbal Ahmad
    Pages 373-396
  13. Qamar Zia, Nishat Fatima, Maroof Alam, Deepa Bisht, Prashant Yadav, Iqbal Ahmad et al.
    Pages 397-421
  14. Mohammad Shahid, Abida Malik, Noor Jahan, Hamdan Ibrahim AL-Mohammed, Ali Ibrahim Al-Sultan, Elsayed Aboulmagd
    Pages 423-448
  15. Farrukh Aqil, Maryam Zahin, Iqbal Ahmad, Mohd Owais, Mohd Sajjad Ahmad Khan, Shyam S. Bansal et al.
    Pages 449-484

About this book

Introduction

The currently available means of combating fungal infections are still weak and clumsy. The application of fungal genomics offers an unparalleled opportunity to develop novel antifungal drugs. Interestingly, several novel antifungal drug targets have already been identified and validated. However, it is too early to expect any novel antifungal drug as drug discovery programs are still in their infancy. In addition to classical and genomic approaches to drug discovery, traditional knowledge derived from natural products and phytomedicine can provide a multitude of alternative modes of combating fungal infection. This book comprises 20 chapters on various aspects pertaining to fungal diseases in human and animals, their reservoir, fungal pathogenesis, their management and recent advances in their treatment. Issues of antifungal drug toxicity, especially nephrotoxicity, are also discussed. The development of resistance in fungal pathogens, including multidrug resistance and its mechanism, is dealt with in two chapters. Diverse diagnostic approaches to fungal infections are also reviewed. The combinational drug strategies used in combating invasive fungal infections are addressed in detail. The management of pulmonary mycoses in stem cell transplantation is also given special focus. Novel antifungal drugs (synthetic and herbal), fungal vaccines, and metabolic pathways as drug targets are discussed in detail in three different chapters. Subsequently the roles of innate immunity, cytokine therapy and immunomodulators in the treatment of fungal infections are elaborated upon. As novel drug delivery systems have a great potential for modifying the pharmacokinetics of medications, the last chapter takes this fact into consideration in its examination of state-of-the-art delivery systems in controlling fungal infections.

Keywords

cytokine diseases drug drug discovery drug resistance fungal infection infection infections innate immunity pathogenesis resistance stem cell transplantation toxicity transplantation vaccine

Editors and affiliations

  • Iqbal Ahmad
    • 1
  • Mohammad Owais
    • 2
  • Mohammed Shahid
    • 3
  • Farrukh Aqil
    • 4
  1. 1.Fac. Agricultural Sciences, Dept. Agricultural MicrobiologyAligarh Muslim UniversityAligarhIndia
  2. 2.Dept. Biochemistry, Interdiciplinary Biotechnology UnitAligarh Muslim UniversityAligarhIndia
  3. 3.J. N. Medical College, Dept. MicrobiologyAligarh Muslim UniversityAligarhIndia
  4. 4.James Graham Brown Cancer CenterLouisvilleUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-12173-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 2010
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-12172-2
  • Online ISBN 978-3-642-12173-9
  • About this book