© 2010

Irreversible Electroporation

  • Boris Rubinsky

Part of the Series in Biomedical Engineering book series (BIOMENG)

Table of contents

  1. Front Matter
  2. Antoni Ivorra, Boris Rubinsky
    Pages 1-21
  3. Avigail Ben-Or, Boris Rubinsky
    Pages 63-83
  4. Rafael V. Davalos, Paulo A. Garcia, Jon F. Edd
    Pages 123-154
  5. Nataša Pavšelj, Damijan Miklavčič
    Pages 183-202
  6. Claudio Bertacchini, Pier Mauro Margotti, Enrico Bergamini, Mattia Ronchetti, Ruggero Cadossi
    Pages 255-272
  7. Alex Golberg, Judith Fischer, Boris Rubinsky
    Pages 273-312
  8. Back Matter

About this book


This is an brief introduction to the emerging field of irreversible electroporation in medicine. Certain electrical fields when applied across a cell can have as a sole effect the permeabilization of the cell membrane, presumable through the formation of nanoscale defects in the cell membrane. Sometimes this process leads to cell death, primarily when the electrical fields cause permanent permeabilization of the membrane and the consequent loss of cell homeostasis, in a process known as irreversible electroporation. This is an unusual mode of cell death that is not fully understood yet. While the phenomenon of irreversible electroporation may have been known for centuries it has become only recently rigorously considered in medicine for various applications of tissue ablation. A brief historical perspective of irreversible electroporation is presentedfollowed by general reviews on the theory and experiment fundamentals and by reports on the most recent theoretical, experimental and clinical studies.


IFMBE cell membrane cells irreversible electroporation oncolog tissue tissue ablation

Editors and affiliations

  • Boris Rubinsky
    • 1
  1. 1.University of California at BerkeleyBerkeleyUSA

Bibliographic information