Diabetes, Insulin and Alzheimer's Disease

  • Suzanne Craft
  • Yves Christen
Part of the Research and Perspectives in Alzheimer's Disease book series (ALZHEIMER)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Alexis M. Stranahan, Mark P. Mattson
    Pages 57-71
  3. Greg M. Cole, Qiu-Lan Ma, Fusheng Yang, Atul Deshpande, Oliver Ubeda, Sally A. Frautschy
    Pages 183-199
  4. Joaquin Piriz, Takeshi Nishijima, Jose Luis Trejo, Ignacio Torres Aleman
    Pages 201-213
  5. Back Matter
    Pages 215-217

About this book

Introduction

Neurons share more similarities with insulin-producing pancreatic islet cells than with any other cell type. The root of this similarity may lie in the islet’s evolution from an ancestral insulin-producing neuron. The islet-neuron connection becomes less surprising as we learn more about insulin’s involvement in functions far from its traditional role in mediating glucose uptake in muscle. The importance of insulin in the regulation of corporal aging has been established by the dramatic increases in longevity experienced by animals in which the adipose insulin receptor has been genetically eliminated, or in which the insulin-related daf genes have been mutated. New research suggests that, analogous to its influence on corporal aging, insulin also makes important contributions to brain aging and the expression of late-life neurodegenerative disease. Insulin plays a key role in cognition and other aspects of normal brain function. Insulin resistance induces chronic peripheral insulin elevations and is associated with reduced insulin activity both in periphery and brain. The insulin resistance syndrome underlies conditions such as Type 2 diabetes mellitus and hypertension, which are associated with age-related cognitive impairment and Alzheimer’s disease.

This book discusses the mechanisms through which insulin dysregulation contributes to the development of cognitive impairment and late-life neurodegenerative disease. Given the recent pandemic of conditions associated with insulin resistance, it is imperative that we achieve a comprehensive knowledge of the mechanisms through which insulin resistance affects brain function in order to develop therapeutic strategies to address these effects.

Keywords

Alzheimer Alzheimer´s disease Diabetes Insulin aging brain-insulin connection growth factor insulin dysregulation insulin resistance insulin signaling system insulin-growth factor insulin-mediated neuroplasticity late-age cognitive disorders;

Editors and affiliations

  • Suzanne Craft
    • 1
  • Yves Christen
    • 2
  1. 1.School of MedicineUniversity of WashingtonSeattleUSA
  2. 2.Recherche TherapeutiqueFondation IPSEN pour laBoulogne Billancourt CedexFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-04300-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 2010
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-04299-7
  • Online ISBN 978-3-642-04300-0
  • Series Print ISSN 0945-6066
  • About this book