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© 2010

Disposable Bioreactors

  • Regine Eibl
  • Dieter Eibl
Book

Part of the Advances in Biochemical Engineering / Biotechnology book series (ABE, volume 115)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Xiaowei Zhang, Matthieu Stettler, Dario De Sanctis, Marco Perrone, Nicola Parolini, Marco Discacciati et al.
    Pages 33-53
  3. Regine Eibl, Sören Werner, Dieter Eibl
    Pages 55-87
  4. Jean-Paul Ducos, Bénédicte Terrier, Didier Courtois
    Pages 89-115
  5. Gerardo Catapano, John F. Patzer II, Jörg Christian Gerlach
    Pages 117-143
  6. Anne Glindkamp, Daniel Riechers, Christoph Rehbock, Bernd Hitzmann, Thomas Scheper, Kenneth F. Reardon
    Pages 145-169
  7. Uwe Gottschalk
    Pages 171-183
  8. Aline Ravisé, Emmanuelle Cameau, Georges De Abreu, Alain Pralong
    Pages 185-219
  9. Back Matter
    Pages 221-223

About this book

Introduction

Over the past five years, the immense financial pressure on the development and manufacturing of biopharmaceuticals has resulted in the increasing use and acce- ance of disposables, which are discarded after harvest and therefore intended only for single use. In fact, such disposables are implemented in all the main bioprocess production stages today and an even higher growth than those in the biopharmac- tical market is predicted (reaching double figures). Alongside disposable filter capsules, membrane chromatography units, tubing, connectors, flexible containers processing or containing fluids, freezer systems, mixers and pumps, and fully c- trolled disposable bioreactors of up to 2,000 L culture volume are already available on the market. Numerous studies highlight the advantages of disposable bioreactors and reveal their potential for simple, safe and fast seed inoculum production, process devel- ment and small as well as middle volume production (e.g. bioactive substances, viruses for vaccines and gene therapies etc.). They suggest that such disposable bioreactors (typically characterized by the cultivation chamber or bag from plastic materials) may be advantageous for plant, animal and microbial cells. Running industrial activities such as CFD-modelling, development of single-use process monitoring and control technology, and standardized film formulations are attempting to resolve the limitations of the current disposable bioreactors. These achievements, along with substantial improvements in product yield, will reduce the use of stainless steel in the biomanufacturing facilities of the future.

Keywords

Biochemistry Bioreactor Biotechnology Downstream Processing Pharmaceuticals Therapeutics Tissue Engineering Transport

Editors and affiliations

  • Regine Eibl
    • 1
  • Dieter Eibl
    • 2
  1. 1.Hochschule WädenswilWädenswilSwitzerland
  2. 2.Hochschule WädenswilWädenswilSwitzerland

Bibliographic information