© 2010

Adverse Drug Reactions

  • Jack Uetrecht

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 196)

Table of contents

  1. Front Matter
    Pages 1-9
  2. Target Organ Toxicity

    1. Front Matter
      Pages 1-1
    2. Michael Holt, Cynthia Ju
      Pages 3-27
    3. Oliver Hausmann, Benno Schnyder, Werner J. Pichler
      Pages 29-55
    4. Richard H. Aster
      Pages 57-76
    5. Thomas D. Nolin, Jonathan Himmelfarb
      Pages 111-130
    6. Peter G. Wells, Crystal J. J. Lee, Gordon P. McCallum, Julia Perstin, Patricia A. Harper
      Pages 131-162
  3. Mediators/Biochemical Pathways

    1. Front Matter
      Pages 164-164
    2. A. Srivastava, J. L. Maggs, D. J. Antoine, D. P. Williams, D. A. Smith, B. K. Park
      Pages 165-194
    3. Mary Jane Masson, Lindsay A. Collins, Lance R. Pohl
      Pages 195-231
    4. Ian M. Copple, Christopher E. Goldring, Neil R. Kitteringham, B. Kevin Park
      Pages 233-266
    5. Derick Han, Mie Shinohara, Maria D. Ybanez, Behnam Saberi, Neil Kaplowitz
      Pages 267-310
    6. Dominique Pessayre, Abdellah Mansouri, Alain Berson, Bernard Fromenty
      Pages 311-365
  4. Examples/Models

    1. Front Matter
      Pages 368-368
    2. Jack A. Hinson, Dean W. Roberts, Laura P. James
      Pages 369-405
    3. M. Keisu, T. B. Andersson
      Pages 407-418
    4. Tsuyoshi Yokoi
      Pages 419-435
    5. M. Popovic, J. M. Shenton, J. Chen, A. Baban, T. Tharmanathan, B. Mannargudi et al.
      Pages 437-451

About this book


This book provides the current state of knowledge of basic mechanisms of adverse drug reactions (ADRs). The main focus is on idiosyncratic drug reactions because they are the most difficult to deal with. It starts with a general description of the major targets for ADRs followed by a description of what are presently believed to be mediators and biochemical pathways involved in idiosyncratic drug reactions. There is also a description of several examples of ADRs that serve to illustrate specific aspects of ADR mechanisms. Eventually the book shows that ultimately better methods are needed to predict which drug candidates are likely to cause ADRs and which patients are at increased risk. But at present research seems to be far from this goal.


Adverse Drug Reactions Drug Hypersensivity Hepatotoxicity Idiosyncratic Drug Reactions blood cytokine drug drug discovery genetics liver necrosis research screening toxicity

Editors and affiliations

  • Jack Uetrecht
    • 1
  1. 1.Faculty of PharmacyUniversity of TorontoTorontoCanada

Bibliographic information