Autophagy in Infection and Immunity

  • Beth Levine
  • Tamotsu Yoshimori
  • Vojo Deretic
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 335)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Zhifen Yang, Daniel J. Klionsky
    Pages 1-32
  3. Audrey Esclatine, Magali Chaumorcel, Patrice Codogno
    Pages 33-70
  4. Noboru Mizushima
    Pages 71-84
  5. Heather H. Pua, You-Wen He
    Pages 85-105
  6. Michal Caspi Tal, Akiko Iwasaki
    Pages 107-121
  7. Monique Gannagé, Christian Münz
    Pages 123-140
  8. Ken Cadwell, Thaddeus S. Stappenbeck, Herbert W. Virgin
    Pages 141-167
  9. Vojo Deretic, Monica Delgado, Isabelle Vergne, Sharon Master, Sergio De Haro, Marisa Ponpuak et al.
    Pages 169-188
  10. Ju Huang, John H. Brumell
    Pages 189-215
  11. Tamotsu Yoshimori, Atsuo Amano
    Pages 217-226
  12. Emanuel Campoy, María I. Colombo
    Pages 227-250
  13. Carlos S. Subauste
    Pages 251-265
  14. Anthony Orvedahl, Beth Levine
    Pages 267-285
  15. Montrell Seay, Andrew P. Hayward, Jeffrey Tsao, S. P. Dinesh-Kumar
    Pages 287-306
  16. Lucile Espert, Martine Biard-Piechaczyk
    Pages 307-321
  17. Back Matter
    Pages 335-339

About this book

Introduction

Autophagy is a fundamental biological process that enables cells to autodigest their own cytosol during starvation and other forms of stress. It has a growing spectrum of acknowledged roles in immunity, aging, development, neurodegeneration, and cancer biology. An immunological role of autophagy was first recognized with the discovery of autophagy’s ability to sanitize the cellular interior by killing intracellular microbes. Since then, the repertoire of autophagy’s roles in immunity has been vastly expanded to include a diverse but interconnected portfolio of regulatory and effector functions. Autophagy is an effector of Th1/Th2 polarization; it fuels MHC II presentation of cytosolic (self and microbial) antigens; it shapes central tolerance; it affects B and T cell homeostasis; it acts both as an effector and a regulator of Toll-like receptor and other innate immunity receptor signaling; and it may help ward off chronic inflammatory disease in humans. With such a multitude of innate and adaptive immunity functions, the study of autophagy in immunity is one of the most rapidly growing fields of contemporary immunological research. This book introduces the reader to the fundamentals of autophagy, guides a novice and the well-informed reader alike through different immunological aspects of autophagy as well as the countermeasures used by highly adapted pathogens to fight autophagy, and provides the expert with the latest, up-to-date information on the specifics of the leading edge of autophagy research in infection and immunity.

Keywords

Antigen apoptosis cell death innate recognition systems intracellular bacteria lymphocyte homeostasis lysosome macroautophagy mitochondria mycobacterium tuberculosis

Editors and affiliations

  • Beth Levine
    • 1
  • Tamotsu Yoshimori
    • 2
  • Vojo Deretic
    • 3
  1. 1.Southwestern Medical CenterUniversity of TexasDallasU.S.A.
  2. 2.Research Inst. Microbial DiseasesOsaka UniversitySuita, OsakaJapan
  3. 3.Health Sciences CenterUniversity of New MexicoAlbuquerqueU.S.A.

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-00302-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 2009
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-00301-1
  • Online ISBN 978-3-642-00302-8
  • Series Print ISSN 0070-217X