Intracellular Traffic and Neurodegenerative Disorders

  • Peter H. St. George-Hyslop
  • William C. C. Mobley
  • Yves Christen

Part of the Research and Perspectives in Alzheimer's Disease book series (ALZHEIMER)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Sam Gandy, Odete da Cruz e Silva, Edgar da Cruz e Silva, Toshiharu Suzuki, Michelle Ehrlich, Scott Small
    Pages 1-9
  3. Erika L. F. Holzbaur
    Pages 27-39
  4. Susan Lindquist, Karen L. Allendoerfer
    Pages 41-57
  5. E.-M. Mandelkow, E. Thies, S. Konzack, E. Mandelkow
    Pages 59-70
  6. Kwok-On Lai, Dan Wang, Kelsey C. Martin
    Pages 71-85
  7. Ahmad Salehi, Chengbiao Wu, Ke Zhan, William C. Mobley
    Pages 87-101
  8. Lawrence Rajendran, Kai Simons
    Pages 103-113
  9. Claire F. Skinner, Matthew N.J. Seaman
    Pages 125-140
  10. Ekaterina Rogaeva, Yan Meng, Joseph H. Lee, Richard Mayeux, Lindsay A. Farrer, Peter St George-Hyslop
    Pages 157-165
  11. Thomas E. Willnow, Michael Rohe, Anne-Sophie Carlo, Vanessa Schmidt
    Pages 167-179
  12. Back Matter
    Pages 181-184

About this book


This book explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. Recent findings point to faulty trafficking as contributing to the dysfunction and degeneration of neurons and neural circuits. Increasingly, research is targeting the mechanisms responsible and means to address them therapeutically. Many adult onset neurodegenerative diseases appear to arise from the accumulation of misfolded, neurotoxic peptides. This book investigates the ways in which sub-cellular trafficking pathways play a role both in the pathological accumulation of these misfolded proteins and in attempts to clear them. Because subcellular protein trafficking has an important role in the biology of neuronal function and survival, this also addresses how trophic factors maintain cell: cell interactions and how the underlying mechanisms may be compromised in neurodegenerative diseases. Examples where the use of such trophic factors may provide a way to modify neurodegenerative diseases are investigated.


Alzheimer Alzheimer's disease Huntingdon's disease amyloid precursor protein axonal transport intramembrane proteolysis membrane trafficking neurodegeneration neurons regulation synapse formation synaptic plasticity

Editors and affiliations

  • Peter H. St. George-Hyslop
    • 1
  • William C. C. Mobley
    • 2
  • Yves Christen
    • 3
  1. 1.Department of Laboratory Medicine and PathobiologyUniversity of TorontoTorontoCanada
  2. 2.Department of NeurologyStandford University School of MedicineStandfordUSA
  3. 3.Fondation IPSEN Pour la Recherche ThérapeutiqueBoulogne BillancourtCedex - France

Bibliographic information