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Gliogenesis: Historical Perspectives, 1839–1985

  • Henry deF. Webster
  • Karl E. Åström

Part of the Advances in Anatomy, Embryology and Cell Biology book series (ADVSANAT, volume 202)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Pages 1-4
  3. Pages 4-37
  4. Pages 37-61
  5. Pages 61-65
  6. Pages 65-66
  7. Pages 66-67
  8. Pages 67-88
  9. Back Matter
    Pages 89-109

About this book

Introduction

This historical review of gliogenesis begins with the introduction of the cell doctrine by Theodor Schwann in 1839. A number of investigators then showed that tissues and organs were made up of cells. However, when Virchow examined the CNS, what separated nerve cells from each other and from blood vessels appeared to be an unstructured ground substance. He called this binding material "glia" (for glue) and thought it was related to connective tissue. Deiters, a pupil of Virchow, discovered that this ground substance was composed of cells, which he described and illustrated. Subsequent improvements in microscope lenses and the introduction of metallic impregnation methods finally permitted the visualization of glial cells and their processes in toto. Light microscopic studies led to the discovery of different types of glial cellsastroglia, oligodendroglia, microglia, ependymal cells in the CNS, and Schwann cells in the PNS. Subsequent observations characterized the origin and development of each type of glial cell. In the 1950s a new era began with the introduction of electron microscopy, tissue culture, and immunocytochemistry. Other techniques and models were developed and exploited in order to better understand the origins of glia and how they multiply, migrate, and differentiate. In this review, morphology is emphasized. Findings related to cytodifferentiation and the cellular interactions, functions, and regulation of developing glia have also been included.

Keywords

Astroglia Ependymal Cells Gliogenesis Microglia Oligodendroglia Schwann Cells Tanycytes Tod cells tissue

Authors and affiliations

  • Henry deF. Webster
    • 1
  • Karl E. Åström
    • 2
  1. 1.Neuroimmunology BranchNational Institute of Neurological Diseases and Stroke MSC: 1400BethesdaUSA
  2. 2.SolnaSweden

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-540-87534-5
  • Copyright Information Springer Berlin Heidelberg 2009
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-87533-8
  • Online ISBN 978-3-540-87534-5
  • Series Print ISSN 0301-5556
  • Buy this book on publisher's site