Table of contents

  1. Front Matter
    Pages i-xvi
  2. Aquaporin Protein Structure and Selectivity Mechanisms

    1. Jennifer M. Carbrey, Peter Agre
      Pages 3-28
    2. Thomas Wspalz, Yoshinori Fujiyoshi, Andreas Engel
      Pages 31-56
    3. Eric Beitz, Dana Becker, Julia von Bülow, Christina Conrad, Nadine Fricke, Amornrat Geadkaew et al.
      Pages 77-92
  3. Aquaporin Function in Mammalian Water Homeostasis

    1. Tae-Hwan Kwon, Jakob Nielsen, Hanne B. Møller, Robert A. Fenton, Søren Nielsen, Jørgen Frøkiær
      Pages 95-132
    2. Pavel I. Nedvetsky, Grazia Tamma, Sven Beulshausen, Giovanna Valenti, Walter Rosenthal, Enno Klussmann
      Pages 133-157
    3. Zsolt Zador, Shirley Stiver, Vincent Wang, Geoffrey T. Manley
      Pages 159-170
  4. Aquaporin Glycerol Permeability in Mammalian Physiology

    1. Mathieu Boury-Jamot, Jean Daraspe, Frédéric Bonté, Eric Perrier, Sylvianne Schnebert, Marc Dumas et al.
      Pages 205-217
    2. Eisei Sohara, Shinichi Uchida, Sei Sasaki
      Pages 219-231
    3. Norikazu Maeda, Toshiyuki Hibuse, Tohru Funahashi
      Pages 233-249
    4. Kenichi Ishibashi
      Pages 251-262
  5. Aquaporin Functions Apart from Water and Glycerol Transport

  6. Towards Therapeutic Use of Aquaporins

    1. Rose Haddoub, Michael Rützler, Aélig Robin, Sabine L. Flitsch
      Pages 385-402

About this book

Introduction

The aquaporin field has matured at an exceptionally fast pace and we are at the verge to develop serious strategies to therapeutically modulate aquaporin function directly or via regulatory networks. Key prerequisites are available today: i. a considerable (and growing) number of aquaporin crystal structures for the rational design of inhibitory molecules, ii. elaborate molecular dynamics simulation techniques for theoretical analyses of selectivity mechanisms and docking experiments, iii. comprehensive data on aquaporin immunohistochemistry, iv. aquaporin knockout animals for physiological studies, and v. assay systems for compound library screenings. The structure of this volume on aquaporins follows the points laid out above and thus covers the developments from basic research to potential pharmacological use. Situated between pharmacology textbooks and recent scientific papers this book provides a timely overview for readers from the fundamental as well as the applied disciplines.

Keywords

aquaporin brain glycerol kidney physiology water homeostasis

Editors and affiliations

  • Eric Beitz
    • 1
  1. 1.Pharmazeutisches Inst.Universität KielKielGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-540-79885-9
  • Copyright Information Springer Berlin Heidelberg 2009
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-79884-2
  • Online ISBN 978-3-540-79885-9
  • Series Print ISSN 0171-2004
  • About this book