© 2008

Ion Channels

  • Editors
  • Bernard Fermini
  • Birgit T. Priest

Part of the Topics in Medicinal Chemistry book series (TMC, volume 3)

Table of contents

  1. Front Matter
    Pages I-XIV
  2. Douglas S. Krafte, Jeff Krajewski, Aaron Gerlach, Mark Suto
    Pages 27-54
  3. Fredrick Van Goor, Sabine Hadida, Peter Grootenhuis
    Pages 91-120
  4. Armando Lagrutta, Laszlo Kiss, Joseph J. Salata
    Pages 145-168
  5. Back Matter
    Pages 169-171

About this book


Ion channels play a vital role in basic physiological functions such as generation of electrical activity in nerves and muscle, control of cardiac excitability, intracellular signaling, hormone secretion, cell proliferation and many other biological processes. Because of their prevalence and the critical role they play in virtually all tissue types and organs, ion channels are also involved in a number of pathophysiological conditions. The aim of this volume is to review recent advances in the field of ion channel related diseases. Following an overview chapter summarizing the current state of ion channel screening technologies, five topics covering areas such as cancer, cardiac arrhythmias, cystic fibrosis, and pain have been selected, and the current state of knowledge is presented by leading experts in their field. Each chapter is structured to cover the biological rationale for the target, the current status in the development of agents to treat the disease, and future prospects and challenges facing each therapeutic area. The reader will receive a critical overview covering the progress made in the rapidly developing and complex field of ion channels and diseases.


Biomedicine Medicinal Chemistry Molecular Chemistry Organic Chemistry Pharmaceutical Chemistry Pharmacy tissue

Bibliographic information