Oncogenes Meet Metabolism

From Deregulated Genes to a Broader Understanding of Tumour Physiology

  • Editors
  • G. Kroemer
  • D. Mumberg
  • H. Keun
  • B. Riefke
  • T. Steger-Hartmann
  • K. Petersen
Conference proceedings

DOI: 10.1007/978-3-540-79478-3

Part of the Ernst Schering Foundation Symposium Proceedings book series (SCHERING FOUND, volume 2007/4)

Table of contents

  1. Front Matter
    Pages i-xv
  2. P. Rustin, G. Kroemer
    Pages 1-21
  3. Y.-L. Chung, J. R. Griffiths
    Pages 55-78
  4. U. Haberkorn, A. Altmann, W. Mier, M. Eisenhut
    Pages 126-152
  5. P. McSheehy, P. Allegrini, S. Ametaby, M. Becquet, T. Ebenhan, M. Honer et al.
    Pages 153-188
  6. S. Rezzi, F-P. J. Martin, S. Kochhar
    Pages 251-264
  7. Back Matter
    Pages 265-265

About these proceedings

Introduction

In 1920s, Otto Warburg described the phenomenon of ‘aerobic glycolysis’, the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg’s hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics).

Keywords

Biomarkers Cancer Research Metabolic Profiling Metabonomics Warburg Effect cells diagnostics physiology tissue

Bibliographic information

  • Copyright Information Springer-Verlag Berlin Heidelberg 2008
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-540-79477-6
  • Online ISBN 978-3-540-79478-3
  • Series Print ISSN 0947-6075