Orphan G Protein-Coupled Receptors and Novel Neuropeptides

  • Editors
  • Olivier Civelli
  • Qun-Yong Zhou

Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 46)

Table of contents

  1. Front Matter
    Pages I-XVI
  2. Olivier Civelli
    Pages 1-25
  3. Steven H. Lin
    Pages 57-88
  4. Masayasu Kojima, Kenji Kangawa
    Pages 89-115
  5. W. H. Colledge
    Pages 117-143
  6. Q.-Y. Zhou, R. Meidan
    Pages 181-199
  7. Kenji Mori, Mikiya Miyazato, Kenji Kangawa
    Pages 201-212
  8. Changlu Liu, Timothy W. Lovenberg
    Pages 213-237
  9. Back Matter
    Pages 257-259

About this book


Over the last decade it has been shown that orphan G protein-coupled receptors (GPCRs) can be used as targets to discover novel neuropeptides. A dozen neuropeptides have been identified through this approach. Each of these neuropeptides has opened new doors for our understanding of fundamental physiological or behavioral responses. For example the orexins, MCH and ghrelin carry fundamental roles in regulating food intake while neuropeptide S, neuromedin S, the prokineticins and the orexins are major players in modulating sleep and circadian rhythms.

The chapters of this book review the latest research in the field, most of them are written by the original discoverers of the respective novel neuropeptide. Emphasis is set not only on their discovery but also on their functional significance. Since many of these neuropeptides are part of drug discovery programs, this book impacts academic as well as pharmaceutical research.


G protein-coupled receptors Orphan GPCR PCR anatomy drug discovery homeostasis neuropeptides physiology prolactin

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2008
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-78350-3
  • Online ISBN 978-3-540-78351-0
  • Series Print ISSN 0080-1844
  • Buy this book on publisher's site