Human Cytomegalovirus

  • Thomas E. Shenk
  • Mark F. Stinski

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 325)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. E. Murphy, Thomas E. Shenk
    Pages 1-19
  3. P. J. Fannin Rider, W. Dunn, E. Yang, F. Liu
    Pages 21-39
  4. Z. Ruzsics, U. H. Koszinowski
    Pages 41-61
  5. C. Sinzger, M. Digel, G. Jahn
    Pages 63-83
  6. M. K. Isaacson, L. K. Juckem, T. Compton
    Pages 85-100
  7. Mark F. Stinski, D. T. Petrik
    Pages 133-152
  8. P. S. Beisser, H. Lavreysen, C. A. Bruggeman, C. Vink
    Pages 221-242
  9. V. Sanchez, D. H. Spector
    Pages 243-262
  10. A. L. McCormick
    Pages 281-295
  11. M. Reeves, J. Sinclair
    Pages 297-313
  12. M. J. Reddehase, C. O. Simon, C. K. Seckert, N. Lemmermann, N. K. A. Grzimek
    Pages 315-331
  13. C. Powers, V. DeFilippis, D. Malouli, K. Früh
    Pages 333-359

About this book

Introduction

The earliest observation of cytomegalovirus (CMV) interactions with the host cell was owl eye cytopathology in various tissues. It was recognized in the early 1970s that human CMV caused in utero infections resulting in congenital brain damage and other sensory neurological complications. Events of the 1980s and early 1990s, such as the wide application of solid organ and bone marrow transplantation and the emergence of AIDS, put the spotlight on human CMV. We understood that the virus was an opportunistic agent associated with immunosuppression. The golden age of cytomegalovirus research was ushered in during the late 1970s and early 1980s by a set of powerful new technologies that included restriction enzymes, DNA cloning, DNA sequencing, and open reading frame prediction. The genetic manipulation and propagation of novel CMV strains was accelerated with the app- cation of bacterial artificial chromosome technology. Today, we still struggle to understand the full spectrum of disease associated with human CMV. To the molecular biologist, CMV is a master of regulation in the eukaryotic cell where it either replicates or remains latent. To the immunologist, CMV is a master of immune evasion with tools to escape both the innate and acquired immune responses. The use of animal models with non-human CMVs has become significantly more sophisticated and tied to a more certain understanding of the interrelationships of non-human and human CMV genes.

Keywords

Chemokine apoptosis cell gene infection placenta protein proteins vaccine virus

Editors and affiliations

  • Thomas E. Shenk
    • 1
  • Mark F. Stinski
    • 2
  1. 1.Princeton UniversityPrincetonUSA
  2. 2.University of IowaIowaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-540-77349-8
  • Copyright Information Springer Berlin Heidelberg 2008
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-77348-1
  • Online ISBN 978-3-540-77349-8
  • Series Print ISSN 0070-217X
  • About this book