ALERT • Adverse Late Effects of Cancer Treatment

Volume 2: Normal Tissue Specific Sites and Systems

  • Philip Rubin
  • Louis S. Constine
  • Lawrence B. Marks

Part of the Medical Radiology book series (MEDRAD)

Also part of the Radiation Oncology book sub series (Med Radiol Radiat Oncol)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Susannah Yovino, Young Kwok, William F. Regine
    Pages 1-20
  3. John P. Kirkpatrick
    Pages 21-48
  4. Thomas E. Merchant, Susan R. Rose
    Pages 49-81
  5. Jasmine H. Francis, Hanna Y. Kim, David H. Abramson
    Pages 83-108
  6. Niranjan Bhandare, Avraham Eisbruch, Patrick J. Antonelli, William M. Mendenhall
    Pages 109-139
  7. Sharon Elad, Cyril Meyerowitz
    Pages 141-166
  8. Bharat Mittal, Yuhchyau Chen, Avraham Eisbruch
    Pages 167-188
  9. Michael T. Milano, Louis S. Constine
    Pages 189-204
  10. Roy H. Decker, Eric A. Strom, Lynn D. Wilson
    Pages 205-226
  11. Julia White, Michael C. Joiner, Liyi Xie
    Pages 227-253
  12. Christopher R. Kelsey, Zeljko Vujaskovic, Isabel Lauren Jackson, Richard F. Riedel, Lawrence B. Marks
    Pages 255-285
  13. Berthe M. P. Aleman, Lena Specht, Ming Hui Chen
    Pages 287-323
  14. Timothy N. Showalter, Maria Werner-Wasik
    Pages 325-351
  15. Stephen L. Harris, Charlie C. Pan, Joel E. Tepper
    Pages 353-394
  16. Laura A. Dawson, Oyedele Adeyi, Anne Horgan, Chandan Guha
    Pages 395-426
  17. Suzanne Russo, Roger Ove, Luis Fajardo, Joel Tepper
    Pages 427-442
  18. Laura A. Dawson, Anne Horgan, Eric P. Cohen
    Pages 443-464
  19. Raymond H. Mak, Akila N. Viswanathan, William U. Shipley
    Pages 465-494
  20. Brett W. Cox, Michael J. Zelefsky
    Pages 495-531
  21. Jill P. Ginsberg, Alan W. Katz
    Pages 533-550
  22. Ann H. Klopp, Patricia J. Eifel
    Pages 551-570
  23. Andre A. Konski, Peter Paximadis
    Pages 571-593
  24. Jane L. Liesveld, Philip Rubin, Louis S. Constine
    Pages 623-655
  25. Jennifer C. Jones, Susan J. Knox
    Pages 685-700

About this book


The literature on the late effects of cancer treatment is widely scattered in different journals since all major organ systems are affected and management is based on a variety of medical and surgical treatments. The aim of ALERT – Adverse Late Effects of Cancer Treatment is to offer a coherent multidisciplinary approach to the care of cancer survivors. The central paradigm is that cytotoxic multimodal therapy results in a perpetual cascade of events that affects each major organ system differently and is expressed continually over time. Essentially, radiation and chemotherapy are intense biologic modifiers that allow for cancer cure and cancer survivorship but accelerate senescence of normal tissues and increase the incidence of age-related diseases and second malignant tumors. Volume 2 of this two-volume work comprehensively documents potential late effects in all the normal tissue anatomic sites in the human body. The detection, diagnosis, management and prevention of effects are all considered in detail, and prognostic outcomes are discussed. Radiation risk factors and interactions with chemotherapy effects are clearly presented. The text is accompanied by numerous supportive illustrations and tables.


Cancer Treatment Chemotherapy Late Effects Radiation Radiotherapy

Editors and affiliations

  • Philip Rubin
    • 1
  • Louis S. Constine
    • 2
  • Lawrence B. Marks
    • 3
  1. 1.Dept. Radiation OncologyUniversity of Rochester Medical Center James P. Wilmot Cancer Ctr.RochesterUSA
  2. 2.Department of Radiation OncologyUniversity of Rochester Medical Center James P. Wilmot Cancer Ctr.RochesterUSA
  3. 3.Department of Radiation OncologyUniversity of North CarolinaChapel HillUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2014
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-540-75862-4
  • Online ISBN 978-3-540-75863-1
  • Series Print ISSN 0942-5373
  • Series Online ISSN 2197-4187
  • Buy this book on publisher's site