Humanized Mice

  • Tatsuji Nomura
  • Takeshi Watanabe
  • Sonoko Habu

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 324)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Tatsuji Nomura, N. Tamaoki, A. Takakura, H. Suemizu
    Pages 1-24
  3. T. Pearson, D. L. Greiner, L. D. Shultz
    Pages 25-51
  4. K. Ando, Y. Muguruma, T. Yahata
    Pages 77-86
  5. M. Ito, M. Shiina, Y. Saito, Y. Tokuda, Y. Kametani, Sonoko Habu
    Pages 95-107
  6. S. Baenziger, P. Ziegler, L. Mazzucchelli, L. Bronz, R. F. Speck, M. G. Manz
    Pages 125-131
  7. Y. Koyanagi, Y. Tanaka, M. Ito, N. Yamamoto
    Pages 133-148
  8. A. K. Wege, M. W. Melkus, P. W. Denton, J. D. Estes, J. V. Garcia
    Pages 149-165
  9. M. Nakamura, H. Suemizu
    Pages 167-177
  10. H. Masuda, H. J. Okano, T. Maruyama, Y. Yoshimura, H. Okano, Y. Matsuzaki
    Pages 179-196
  11. Back Matter
    Pages 197-199

About this book

Introduction

The term humanized mouse in this text refers to a mouse in which human tissues and cells have been transplanted and show the same biological function as they do in the human body. That is, the physiological properties and functions of tra- planted human tissues and cells can be analyzed in the mouse instead of using a living human body. It should therefore be possible to study the pathophysiology and treatment of human diseases in mice with good reproducibility. Thus, the hum- ized mouse can be used as a potent tool in both basic and clinical research in the future. The development of appropriate immunodeficient mice has been indispensable in the creation of the humanized mouse, which has been achieved through many years of efforts by several laboratories. The first stage on the road to the humanized mouse was the report on nude mice by Isaacson and Cattanach in 1962. Thereafter, nude mice were studied in detail by Falanagan and, in 1968, Pantelouris found that these mice have no thymus gland, which suggested that the mice lack transplan- tion immunity against xenografts such as human hematopoietic stem cells. At the Nude Mouse Workshops (organized by Regard, Povlsen, Nomura and colleagues) that were held nine times between 1972 and 1997, the possibility of creating a humanized mouse using nude mice was extensively examined. The results, however, showed that certain human cancers can be engrafted in nude mice, but unfortunately engraftment of normal human tissue was almost impossible.

Keywords

Antigen HIV Laboratory T cell bone cells development diseases immune system immunity infection pathophysiology physiology tissue virus

Editors and affiliations

  • Tatsuji Nomura
    • 1
  • Takeshi Watanabe
    • 2
  • Sonoko Habu
    • 3
  1. 1.Central Institute for Experimental AnimalsJapan
  2. 2.RIKENJapan
  3. 3.Tokai University School of MedicineJapan

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-540-75647-7
  • Copyright Information Springer Berlin Heidelberg 2008
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-540-75646-0
  • Online ISBN 978-3-540-75647-7
  • Series Print ISSN 0070-217X
  • About this book