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RNA Interference

  • Patrick J. Paddison
  • Peter K. Vogt
Book

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 320)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Patrick J. Paddison
    Pages 1-19
  3. Marie-Eve L. Boisvert, Martin J. Simard
    Pages 21-36
  4. Harsh H. Kavi, Harvey Fernandez, Weiwu Xie, James A. Birchler
    Pages 37-75
  5. Lukasz Jaskiewicz, Witold Filipowicz
    Pages 77-97
  6. Xuemei Chen
    Pages 117-136
  7. Kenneth K.-S. Ng, Jamie J. Arnold, Craig E. Cameron
    Pages 137-156
  8. Sharon A. White, Robin C. Allshire
    Pages 157-183
  9. Nicole C. Riddle, Sarah C. R. Elgin
    Pages 185-209
  10. Isaac Bentwich
    Pages 257-269
  11. Back Matter
    Pages 271-276

About this book

Introduction

In the last few years the major effect that RNAi has had in invertebrate systems like C.elegans and drosophila is beginning to take hold in mammalian systems through both single gene knockdown experiments and genome-scale screens. In the next decade, there will no doubt be both notable successes and failures as we attempt to apply this genetic tool to various biological problems for the first time in academia and industry. Through the introduction of RNAi, mammalian systems have finally gained admittance to the pantheon of model genetic systems.

Keywords

RNA RNAi pathway biochemistry cell chemistry chromatin gene genetics mammalian oocytes metabolism microRNA plants polymer transcription yeast

Editors and affiliations

  • Patrick J. Paddison
    • 1
  • Peter K. Vogt
    • 2
  1. 1.Cold Spring Harbor LaboratoryCold Spring Harbor Fellows ProgramCold Spring Harbor
  2. 2.Department of Molecular & Experimental Medicine Division of OncovirologyThe Scripps Research InstituteLa JollaUSA

Bibliographic information