The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies

  • Michael Molls
  • Peter Vaupel
  • Carsten Nieder
  • Mitchell S. Anscher

Part of the Medical Radiology book series (MEDRAD)

Table of contents

  1. Front Matter
    Pages I-X
  2. Michael J. Atkinson, Soile Tapio
    Pages 1-17
  3. Marek Los, Iran Rashedi, Soumya Panigrahi, Thomas Klonisch, Klaus Schulze-Osthoff
    Pages 19-37
  4. Vesile Schneider, Hans Christian Rischke, Joachim Drevs
    Pages 39-50
  5. Peter Vaupel
    Pages 51-92
  6. Nils Cordes, Stephanie Hehlgans, Iris Eke
    Pages 93-115
  7. Miodrag Gužvić, Christoph A. Klein
    Pages 117-128
  8. Gabriele Multhoff, Sabrina T. Astner
    Pages 129-145
  9. Carsten Nieder, Adam Pawinski
    Pages 147-151
  10. Michael Molls, Carsten Nieder, Claus Belka, Jan Norum
    Pages 169-190
  11. Shiyu Song, Paul Dent, Steven Grant
    Pages 191-219
  12. Isabel L. Jackson, Mitchell S. Anscher, Zeljko Vujaskovic
    Pages 221-241
  13. George Iliakis, Jochen Dahm-Daphi, Ekkehard Dikomey
    Pages 251-271
  14. Angela M. Kaindl, Konrad Oexle
    Pages 299-311
  15. Kristoffer Valerie, Paul R. Graves
    Pages 313-321
  16. Michael Baumann, Mechthild Krause
    Pages 323-334
  17. Satoshi Itasaka, Masahiro Hiraoka
    Pages 347-354
  18. Back Matter
    Pages 355-367

About this book


This book provides an overview of the fundamentals of tumor biology and the influence of various biologic factors, including inhomogeneity of cancer cells, microenvironment, and host factors, on the design of therapeutic strategies and the outcome of established and emerging treatments. Particular attention is devoted to multidisciplinary combined modality therapy. The topics reviewed include tumorigenesis, cell proliferation, angiogenesis, physiology of malignant tissues, adhesion and invasion, development of metastases, and the role of the immune system in cancer development. Subsequent chapters focus on cancer prevention, detection, and treatment. The principles of chemotherapy, radiotherapy, and molecularly targeted therapy are discussed, treatment resistance is explained, and strategies for rational combinations are provided, including the design of translational studies. Furthermore, the principles and clinical implications of new diagnostic and therapeutic approaches, such as gene expression profiling, gene transfer and silencing, proteomics, and molecular imaging, are presented. The chapters in this book have been written by an outstanding group of basic scientists, clinical researchers, and cancer professionals with long experience in the field. Their aim is to educate and inspire all those who devote most of their work to research into cancer and its treatment.


Cancer Cancer Biology Cancer Treatment Chemotherapy Radiotherapy Tumor angiogenesis imaging positron emission tomography tumor growth tumorigenesis

Editors and affiliations

  • Michael Molls
    • 1
  • Peter Vaupel
    • 2
  • Carsten Nieder
    • 3
  • Mitchell S. Anscher
    • 4
  1. 1.Klinik und Poliklinik für Strahlentherapie und Radiologische OnkologieKlinikum Rechts der Isar der Technischen Universität MünchenMünchenGermany
  2. 2.Institute of Physiology and PathophysiologyUniversity Medical CenterMainzGermany
  3. 3.Department of Internal Medicine – OncologyNordlandssykehuset HF HospitalBodøNorway
  4. 4.Department of Radiation OncologyVirginia Commonwealth University School of MedicineRichmondUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Berlin Heidelberg 2009
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-540-74385-9
  • Online ISBN 978-3-540-74386-6
  • Series Print ISSN 0942-5373
  • Buy this book on publisher's site